Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling

Jun Yin, Emma Spillman, Ethan S. Cheng, Jacob Short, Yang Chen, Jingce Lei, Mary Gibbs, Justin S. Rosenthal, Chengyu Sheng, Yuki X. Chen, Kelly Veerasammy, Tenzin Choetso, Rinat Abzalimov, Bei Wang, Chun Han, Ye He and Quan Yuan ()
Additional contact information
Jun Yin: National Institutes of Health
Emma Spillman: National Institutes of Health
Ethan S. Cheng: National Institutes of Health
Jacob Short: National Institutes of Health
Yang Chen: National Institutes of Health
Jingce Lei: National Institutes of Health
Mary Gibbs: National Institutes of Health
Justin S. Rosenthal: National Institutes of Health
Chengyu Sheng: National Institutes of Health
Yuki X. Chen: The City University of New York, Graduate Center-Advanced Science Research Center
Kelly Veerasammy: The City University of New York, Graduate Center-Advanced Science Research Center
Tenzin Choetso: The City University of New York, Graduate Center-Advanced Science Research Center
Rinat Abzalimov: The City University of New York, Graduate Center-Advanced Science Research Center
Bei Wang: Cornell University
Chun Han: Cornell University
Ye He: The City University of New York, Graduate Center-Advanced Science Research Center
Quan Yuan: National Institutes of Health

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Lipid shuttling between neurons and glia contributes to the development, function, and stress responses of the nervous system. To understand how a neuron acquires its lipid supply from specific lipoproteins and their receptors, we perform combined genetic, transcriptome, and biochemical analyses in the developing Drosophila larval brain. Here we report, the astrocyte-derived secreted lipocalin Glial Lazarillo (GLaz), a homolog of human Apolipoprotein D (APOD), and its neuronal receptor, the brain-specific short isoforms of Drosophila lipophorin receptor 1 (LpR1-short), cooperatively mediate neuron-glia lipid shuttling and support dendrite morphogenesis. The isoform specificity of LpR1 defines its distribution, binding partners, and ability to support proper dendrite growth and synaptic connectivity. By demonstrating physical and functional interactions between GLaz/APOD and LpR1, we elucidate molecular pathways mediating lipid trafficking in the fly brain, and provide in vivo evidence indicating isoform-specific expression of lipoprotein receptors as a key mechanism for regulating cell-type specific lipid recruitment.

Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-22751-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22751-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-22751-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().