Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

Irma Karabegović, Eliana Portilla-Fernandez, Yang Li, Jiantao Ma, Silvana C. E. Maas, Daokun Sun, Emily A. Hu, Brigitte Kühnel, Yan Zhang, Srikant Ambatipudi, Giovanni Fiorito, Jian Huang, Juan E. Castillo-Fernandez, Kerri L. Wiggins, Niek Klein, Sara Grioni, Brenton R. Swenson, Silvia Polidoro, Jorien L. Treur, Cyrille Cuenin, Pei-Chien Tsai, Ricardo Costeira, Veronique Chajes, Kim Braun, Niek Verweij, Anja Kretschmer, Lude Franke, Joyce B. J. Meurs, André G. Uitterlinden, Robert J. Knegt, M. Arfan Ikram, Abbas Dehghan, Annette Peters, Ben Schöttker, Sina A. Gharib, Nona Sotoodehnia, Jordana T. Bell, Paul Elliott, Paolo Vineis, Caroline Relton, Zdenko Herceg, Hermann Brenner, Melanie Waldenberger, Casey M. Rebholz, Trudy Voortman, Qiuwei Pan, Myriam Fornage, Daniel Levy, Manfred Kayser and Mohsen Ghanbari ()
Additional contact information
Irma Karabegović: Erasmus University Medical Center
Eliana Portilla-Fernandez: Erasmus University Medical Center
Yang Li: Erasmus University Medical Center
Jiantao Ma: Tufts University
Silvana C. E. Maas: Erasmus University Medical Center
Daokun Sun: University of Texas Health Science Center at Houston
Emily A. Hu: Johns Hopkins Bloomberg School of Public Health
Brigitte Kühnel: German Research Center for Environmental Health
Yan Zhang: German Cancer Research Center (DKFZ)
Srikant Ambatipudi: University of Bristol
Giovanni Fiorito: University of Sassari
Jian Huang: Imperial College London, Norfolk Place
Juan E. Castillo-Fernandez: Kings College London
Kerri L. Wiggins: CHRU
Niek Klein: University Medical Center Groningen, University of Groningen
Sara Grioni: IRCCS National Cancer Institute Foundation
Brenton R. Swenson: CHRU
Silvia Polidoro: Imperial College London, Norfolk Place
Jorien L. Treur: Amsterdam UMC
Cyrille Cuenin: International Agency for Research on Cancer (IARC)
Pei-Chien Tsai: Kings College London
Ricardo Costeira: Kings College London
Veronique Chajes: International Agency for Research on Cancer
Kim Braun: Erasmus University Medical Center
Niek Verweij: University Medical Center Groningen, University of Groningen
Anja Kretschmer: German Research Center for Environmental Health
Lude Franke: University Medical Center Groningen, University of Groningen
Joyce B. J. Meurs: Erasmus University Medical Center
André G. Uitterlinden: Erasmus University Medical Center
Robert J. Knegt: Erasmus University Medical Center
M. Arfan Ikram: Erasmus University Medical Center
Abbas Dehghan: Imperial College London, Norfolk Place
Annette Peters: German Research Center for Environmental Health
Ben Schöttker: German Cancer Research Center (DKFZ)
Sina A. Gharib: University of Washington
Nona Sotoodehnia: CHRU
Jordana T. Bell: Kings College London
Paul Elliott: Imperial College London, Norfolk Place
Paolo Vineis: Imperial College London, Norfolk Place
Caroline Relton: University of Bristol
Zdenko Herceg: International Agency for Research on Cancer (IARC)
Hermann Brenner: German Cancer Research Center (DKFZ)
Melanie Waldenberger: German Research Center for Environmental Health
Casey M. Rebholz: Johns Hopkins Bloomberg School of Public Health
Trudy Voortman: Erasmus University Medical Center
Qiuwei Pan: Erasmus University Medical Center
Myriam Fornage: University of Texas Health Science Center at Houston
Daniel Levy: National Institutes of Health, Bethesda, Maryland and the Framingham Heart Study
Manfred Kayser: Erasmus University Medical Center
Mohsen Ghanbari: Erasmus University Medical Center

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value

Date: 2021
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DOI: 10.1038/s41467-021-22752-6

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