Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

Edward A. Hayter, Sophie M. T. Wehrens, Hans P. A. Dongen, Alessandra Stangherlin, Shobhan Gaddameedhi, Elena Crooks, Nichola J. Barron, Luigi A. Venetucci, John S. O’Neill, Timothy M. Brown, Debra J. Skene, Andrew W. Trafford and David A. Bechtold ()
Additional contact information
Edward A. Hayter: University of Manchester
Sophie M. T. Wehrens: University of Surrey
Hans P. A. Dongen: Washington State University
Alessandra Stangherlin: MRC Laboratory of Molecular Biology
Shobhan Gaddameedhi: North Carolina State University
Elena Crooks: Washington State University
Nichola J. Barron: University of Manchester
Luigi A. Venetucci: University of Manchester
John S. O’Neill: MRC Laboratory of Molecular Biology
Timothy M. Brown: University of Manchester
Debra J. Skene: University of Surrey
Andrew W. Trafford: University of Manchester
David A. Bechtold: University of Manchester

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily rhythms in sinoatrial (SA) and atrioventricular (AV) node activity, and impose a time-of–day dependent susceptibility to ventricular arrhythmia. Critically, the balance of circadian inputs from the autonomic nervous system and cardiomyocyte clock to the SA and AV nodes differ, and this renders the cardiac conduction system sensitive to decoupling during abrupt shifts in behavioural routine and sleep-wake timing. Our findings reveal a functional segregation of circadian control across the heart’s conduction system and inherent susceptibility to arrhythmia.

Date: 2021
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DOI: 10.1038/s41467-021-22788-8

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