Oocyte-derived microvilli control female fertility by optimizing ovarian follicle selection in mice

Yan Zhang, Ye Wang, Xie’an Feng, Shuo Zhang, Xueqiang Xu, Lingyu Li, Shudong Niu, Yingnan Bo, Chao Wang, Zhen Li, Guoliang Xia and Hua Zhang ()
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Yan Zhang: China Agricultural University
Ye Wang: China Agricultural University
Xie’an Feng: China Agricultural University
Shuo Zhang: China Agricultural University
Xueqiang Xu: China Agricultural University
Lingyu Li: China Agricultural University
Shudong Niu: China Agricultural University
Yingnan Bo: China Agricultural University
Chao Wang: China Agricultural University
Zhen Li: China Agricultural University
Guoliang Xia: China Agricultural University
Hua Zhang: China Agricultural University

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Crosstalk between oocytes and surrounding somatic cells is crucial for mammalian oogenesis, but the structural mechanisms on oocytes to control female reproduction remain unknown. Here we combine endogenous-fluorescent tracing mouse models with a high-resolution live-cell imaging system to characterize oocyte-derived mushroom-like microvilli (Oo-Mvi), which mediate germ-somatic communication in mice. We perform 3D live-cell imaging to show that Oo-Mvi exhibit cellular characteristics that fit an exocrine function for signaling communication. We find that deletion of the microvilli-forming gene Radixin in oocytes leads to the loss of Oo-Mvi in ovaries, and causes a series of abnormalities in ovarian development, resulting in shortened reproductive lifespan in females. Mechanistically, we find that Oo-Mvi enrich oocyte-secreted factors and control their release, resulting in optimal selection of ovarian follicles. Taken together, our data show that the Oo-Mvi system controls the female reproductive lifespan by governing the fate of follicles.

Date: 2021
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DOI: 10.1038/s41467-021-22829-2

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