Interplay of two transcription factors for recruitment of the chromatin remodeling complex modulates fungal nitrosative stress response

Yunqing Jian, Zunyong Liu, Haixia Wang, Yun Chen, Yanni Yin, Youfu Zhao and Zhonghua Ma ()
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Yunqing Jian: Zhejiang University
Zunyong Liu: Zhejiang University
Haixia Wang: Zhejiang University
Yun Chen: Zhejiang University
Yanni Yin: Zhejiang University
Youfu Zhao: University of Illinois at Urbana-Champaign
Zhonghua Ma: Zhejiang University

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Nitric oxide (NO) is a diffusible signaling molecule that modulates animal and plant immune responses. In addition, reactive nitrogen species derived from NO can display antimicrobial activities by reacting with microbial cellular components, leading to nitrosative stress (NS) in pathogens. Here, we identify FgAreB as a regulator of the NS response in Fusarium graminearum, a fungal pathogen of cereal crops. FgAreB serves as a pioneer transcription factor for recruitment of the chromatin-remodeling complex SWI/SNF at the promoters of genes involved in the NS response, thus promoting their transcription. FgAreB plays important roles in fungal infection and growth. Furthermore, we show that a transcription repressor (FgIxr1) competes with the SWI/SNF complex for FgAreB binding, and negatively regulates the NS response. NS, in turn, promotes the degradation of FgIxr1, thus enhancing the recruitment of the SWI/SNF complex by FgAreB.

Date: 2021
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DOI: 10.1038/s41467-021-22831-8

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