Bidirectional propagation of low frequency oscillations over the human hippocampal surface

Jonathan K. Kleen, Jason E. Chung, Kristin K. Sellers, Jenny Zhou, Michael Triplett, Kye Lee, Angela Tooker, Razi Haque and Edward F. Chang ()
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Jonathan K. Kleen: University of California San Francisco
Jason E. Chung: University of California San Francisco
Kristin K. Sellers: University of California San Francisco
Jenny Zhou: Lawrence Livermore National Laboratories
Michael Triplett: Lawrence Livermore National Laboratories
Kye Lee: Lawrence Livermore National Laboratories
Angela Tooker: Lawrence Livermore National Laboratories
Razi Haque: Lawrence Livermore National Laboratories
Edward F. Chang: University of California San Francisco

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract The hippocampus is diversely interconnected with other brain systems along its axis. Cycles of theta-frequency activity are believed to propagate from the septal to temporal pole, yet it is unclear how this one-way route supports the flexible cognitive capacities of this structure. We leveraged novel thin-film microgrid arrays conformed to the human hippocampal surface to track neural activity two-dimensionally in vivo. All oscillation frequencies identified between 1–15 Hz propagated across the tissue. Moreover, they dynamically shifted between two roughly opposite directions oblique to the long axis. This predominant propagation axis was mirrored across participants, hemispheres, and consciousness states. Directionality was modulated in a participant who performed a behavioral task, and it could be predicted by wave amplitude topography over the hippocampal surface. Our results show that propagation directions may thus represent distinct meso-scale network computations, operating along versatile spatiotemporal processing routes across the hippocampal body.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22850-5

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DOI: 10.1038/s41467-021-22850-5

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