Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

Ko Tsutsui, Hiroki Machida, Asako Nakagawa, Kyungmin Ahn, Ritsuko Morita, Kiyotoshi Sekiguchi, Jeffrey H. Miner and Hironobu Fujiwara ()
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Ko Tsutsui: Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)
Hiroki Machida: Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)
Asako Nakagawa: Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)
Kyungmin Ahn: Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)
Ritsuko Morita: Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)
Kiyotoshi Sekiguchi: Institute for Protein Research, Osaka University
Jeffrey H. Miner: Washington University School of Medicine
Hironobu Fujiwara: Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)

Nature Communications, 2021, vol. 12, issue 1, 1-18

Abstract: Abstract Inter-tissue interaction is fundamental to multicellularity. Although the basement membrane (BM) is located at tissue interfaces, its mode of action in inter-tissue interactions remains poorly understood, mainly because the molecular and structural details of the BM at distinct inter-tissue interfaces remain unclear. By combining quantitative transcriptomics and immunohistochemistry, we systematically identify the cellular origin, molecular identity and tissue distribution of extracellular matrix molecules in mouse hair follicles, and reveal that BM composition and architecture are exquisitely specialized for distinct inter-tissue interactions, including epithelial–fibroblast, epithelial–muscle and epithelial–nerve interactions. The epithelial–fibroblast interface, namely, hair germ–dermal papilla interface, makes asymmetrically organized side-specific heterogeneity in the BM, defined by the newly characterized interface, hook and mesh BMs. One component of these BMs, laminin α5, is required for hair cycle regulation and hair germ–dermal papilla anchoring. Our study highlights the significance of BM heterogeneity in distinct inter-tissue interactions.

Date: 2021
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DOI: 10.1038/s41467-021-22881-y

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