Connectivity characterization of the mouse basolateral amygdalar complex

Houri Hintiryan (), Ian Bowman, David L. Johnson, Laura Korobkova, Muye Zhu, Neda Khanjani, Lin Gou, Lei Gao, Seita Yamashita, Michael S. Bienkowski, Luis Garcia, Nicholas N. Foster, Nora L. Benavidez, Monica Y. Song, Darrick Lo, Kaelan R. Cotter, Marlene Becerra, Sarvia Aquino, Chunru Cao, Ryan P. Cabeen, Jim Stanis, Marina Fayzullina, Sarah A. Ustrell, Tyler Boesen, Amanda J. Tugangui, Zheng-Gang Zhang, Bo Peng, Michael S. Fanselow, Peyman Golshani, Joel D. Hahn, Ian R. Wickersham, Giorgio A. Ascoli, Li I. Zhang and Hong-Wei Dong ()
Additional contact information
Houri Hintiryan: University of Southern California
Ian Bowman: University of Southern California
David L. Johnson: University of Southern California
Laura Korobkova: University of Southern California
Muye Zhu: University of Southern California
Neda Khanjani: University of Southern California
Lin Gou: University of Southern California
Lei Gao: University of Southern California
Seita Yamashita: University of Southern California
Michael S. Bienkowski: University of Southern California
Luis Garcia: University of Southern California
Nicholas N. Foster: University of Southern California
Nora L. Benavidez: University of Southern California
Monica Y. Song: University of Southern California
Darrick Lo: University of Southern California
Kaelan R. Cotter: University of Southern California
Marlene Becerra: University of Southern California
Sarvia Aquino: University of Southern California
Chunru Cao: University of Southern California
Ryan P. Cabeen: University of Southern California
Jim Stanis: University of Southern California
Marina Fayzullina: University of Southern California
Sarah A. Ustrell: University of Southern California
Tyler Boesen: University of Southern California
Amanda J. Tugangui: University of Southern California
Zheng-Gang Zhang: University of Southern California
Bo Peng: University of Southern California
Michael S. Fanselow: University of California
Peyman Golshani: University of California
Joel D. Hahn: University of Southern California
Ian R. Wickersham: Massachusetts Institute of Technology
Giorgio A. Ascoli: George Mason University
Li I. Zhang: University of Southern California
Hong-Wei Dong: University of Southern California

Nature Communications, 2021, vol. 12, issue 1, 1-25

Abstract: Abstract The basolateral amygdalar complex (BLA) is implicated in behaviors ranging from fear acquisition to addiction. Optogenetic methods have enabled the association of circuit-specific functions to uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile of BLA projection neurons to inform granular, cell type-specific interrogations is warranted. Here, we apply machine-learning based computational and informatics analysis techniques to the results of circuit-tracing experiments to create a foundational, comprehensive BLA connectivity map. The analyses identify three distinct domains within the anterior BLA (BLAa) that house target-specific projection neurons with distinguishable morphological features. We identify brain-wide targets of projection neurons in the three BLAa domains, as well as in the posterior BLA, ventral BLA, posterior basomedial, and lateral amygdalar nuclei. Inputs to each nucleus also are identified via retrograde tracing. The data suggests that connectionally unique, domain-specific BLAa neurons are associated with distinct behavior networks.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22915-5

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DOI: 10.1038/s41467-021-22915-5

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