Taxonomic signatures of cause-specific mortality risk in human gut microbiome

Aaro Salosensaari, Ville Laitinen, Aki S. Havulinna, Guillaume Meric, Susan Cheng, Markus Perola, Liisa Valsta, Georg Alfthan, Michael Inouye, Jeramie D. Watrous, Tao Long, Rodolfo A. Salido, Karenina Sanders, Caitriona Brennan, Gregory C. Humphrey, Jon G. Sanders, Mohit Jain, Pekka Jousilahti, Veikko Salomaa, Rob Knight, Leo Lahti () and Teemu Niiranen ()
Additional contact information
Aaro Salosensaari: Turku University Hospital and University of Turku
Ville Laitinen: University of Turku
Aki S. Havulinna: Finnish Institute for Health and Welfare
Guillaume Meric: Baker Heart and Diabetes Institute
Susan Cheng: Brigham and Women’s Hospital
Markus Perola: Finnish Institute for Health and Welfare
Liisa Valsta: Finnish Institute for Health and Welfare
Georg Alfthan: Finnish Institute for Health and Welfare
Michael Inouye: Baker Heart and Diabetes Institute
Jeramie D. Watrous: University of California San Diego
Tao Long: University of California San Diego
Rodolfo A. Salido: University of California San Diego
Karenina Sanders: University of California San Diego
Caitriona Brennan: University of California San Diego
Gregory C. Humphrey: University of California San Diego
Jon G. Sanders: University of California San Diego
Mohit Jain: University of California San Diego
Pekka Jousilahti: Finnish Institute for Health and Welfare
Veikko Salomaa: Finnish Institute for Health and Welfare
Rob Knight: University of California San Diego
Leo Lahti: University of Turku
Teemu Niiranen: Turku University Hospital and University of Turku

Nature Communications, 2021, vol. 12, issue 1, 1-8

Abstract: Abstract The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland (n = 7211). We report robust taxonomic and functional microbiome signatures related to the Enterobacteriaceae family that are associated with mortality risk during a 15-year follow-up. Our results extend previous cross-sectional studies, and help to establish the basis for examining long-term associations between human gut microbiome composition, incident outcomes, and general health status.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22962-y

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DOI: 10.1038/s41467-021-22962-y

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