A sand fly salivary protein acts as a neutrophil chemoattractant

Anderson B. Guimaraes-Costa, John P. Shannon, Ingrid Waclawiak, Jullyanna Oliveira, Claudio Meneses, Waldione Castro, Xi Wen, Joseph Brzostowski, Tiago D. Serafim, John F. Andersen, Heather D. Hickman, Shaden Kamhawi, Jesus G. Valenzuela () and Fabiano Oliveira ()
Additional contact information
Anderson B. Guimaraes-Costa: National Institutes of Health
John P. Shannon: National Institutes of Health
Ingrid Waclawiak: Universidade Federal do Rio de Janeiro
Jullyanna Oliveira: Universidade Federal do Rio de Janeiro
Claudio Meneses: National Institutes of Health
Waldione Castro: National Institutes of Health
Xi Wen: National Institute of Allergy and Infectious Diseases, NIH
Joseph Brzostowski: National Institute of Allergy and Infectious Diseases, NIH
Tiago D. Serafim: National Institutes of Health
John F. Andersen: National Institutes of Health
Heather D. Hickman: National Institutes of Health
Shaden Kamhawi: National Institutes of Health
Jesus G. Valenzuela: National Institutes of Health
Fabiano Oliveira: National Institutes of Health

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Apart from bacterial formyl peptides or viral chemokine mimicry, a non-vertebrate or insect protein that directly attracts mammalian innate cells such as neutrophils has not been molecularly characterized. Here, we show that members of sand fly yellow salivary proteins induce in vitro chemotaxis of mouse, canine and human neutrophils in transwell migration or EZ-TAXIScan assays. We demonstrate murine neutrophil recruitment in vivo using flow cytometry and two-photon intravital microscopy in Lysozyme-M-eGFP transgenic mice. We establish that the structure of this ~ 45 kDa neutrophil chemotactic protein does not resemble that of known chemokines. This chemoattractant acts through a G-protein-coupled receptor and is dependent on calcium influx. Of significance, this chemoattractant protein enhances lesion pathology (P

Date: 2021
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DOI: 10.1038/s41467-021-23002-5

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