Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Thi H. O. Nguyen, Marios Koutsakos, Carolien E. Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K. Allen, Tim Brahm, E. Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nüssing, Xiaoxiao Jia, Patrick Günther, Adam K. Wheatley, Stephen J. Kent, Malet Aban, Yi-Mo Deng, Karen L. Laurie, Aeron C. Hurt, Stephanie Gras, Jamie Rossjohn, Jane Crowe, Jianqing Xu, David Jackson, Lorena E. Brown, Nicole Gruta, Weisan Chen, Peter C. Doherty, Stephen J. Turner, Tom C. Kotsimbos, Paul G. Thomas, Allen C. Cheng () and Katherine Kedzierska ()
Additional contact information
Thi H. O. Nguyen: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Marios Koutsakos: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Carolien E. Sandt: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Jeremy Chase Crawford: St Jude Children’s Research Hospital
Liyen Loh: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Sneha Sant: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Ludivine Grzelak: École Normale Supérieure Paris-Saclay, Université Paris-Saclay Cachan
Emma K. Allen: St Jude Children’s Research Hospital
Tim Brahm: St Jude Children’s Research Hospital
E. Bridie Clemens: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Maria Auladell: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Luca Hensen: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Zhongfang Wang: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Simone Nüssing: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Xiaoxiao Jia: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Patrick Günther: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Adam K. Wheatley: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Stephen J. Kent: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Malet Aban: at The Peter Doherty Institute for Infection and Immunity
Yi-Mo Deng: at The Peter Doherty Institute for Infection and Immunity
Karen L. Laurie: at The Peter Doherty Institute for Infection and Immunity
Aeron C. Hurt: at The Peter Doherty Institute for Infection and Immunity
Stephanie Gras: Biomedicine Discovery Institute, Monash University
Jamie Rossjohn: Biomedicine Discovery Institute, Monash University
Jane Crowe: Deepdene Surgery
Jianqing Xu: Shanghai Medical College, Fudan University
David Jackson: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Lorena E. Brown: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Nicole Gruta: Biomedicine Discovery Institute, Monash University
Weisan Chen: La Trobe Institute For Molecular Science, La Trobe University
Peter C. Doherty: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
Stephen J. Turner: Biomedicine Discovery Institute, Monash University
Tom C. Kotsimbos: The Alfred Hospital
Paul G. Thomas: St Jude Children’s Research Hospital
Allen C. Cheng: Monash University
Katherine Kedzierska: University of Melbourne, at the Peter Doherty Institute for Infection and Immunity

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one single study. Here, we utilize longitudinal samples from patients hospitalized with acute influenza to understand these immune responses. We report the dynamics of 18 important immune parameters, related to clinical, genetic and virological factors, in influenza patients across different severity levels. Influenza disease correlates with increases in IL-6/IL-8/MIP-1α/β cytokines and lower antibody responses. Robust activation of circulating T follicular helper cells correlates with peak antibody-secreting cells and influenza heamaglutinin-specific memory B-cell numbers, which phenotypically differs from vaccination-induced B-cell responses. Numbers of influenza-specific CD8+ or CD4+ T cells increase early in disease and retain an activated phenotype during patient recovery. We report the characterisation of immune cellular networks underlying recovery from influenza infection which are highly relevant to other infectious diseases.

Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-23018-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23018-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-23018-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().