Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform

Wei A. Huang, Iain M. Stitt, Ehsan Negahbani, D. J. Passey, Sangtae Ahn, Marshall Davey, Moritz Dannhauer, Thien T. Doan, Anna C. Hoover, Angel V. Peterchev, Susanne Radtke-Schuller and Flavio Fröhlich ()
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Wei A. Huang: University of North Carolina
Iain M. Stitt: University of North Carolina
Ehsan Negahbani: University of North Carolina
D. J. Passey: University of North Carolina
Sangtae Ahn: University of North Carolina
Marshall Davey: University of North Carolina
Moritz Dannhauer: Duke University
Thien T. Doan: Duke University
Anna C. Hoover: Duke University
Angel V. Peterchev: Duke University
Susanne Radtke-Schuller: University of North Carolina
Flavio Fröhlich: University of North Carolina

Nature Communications, 2021, vol. 12, issue 1, 1-20

Abstract: Abstract Computational modeling and human studies suggest that transcranial alternating current stimulation (tACS) modulates alpha oscillations by entrainment. Yet, a direct examination of how tACS interacts with neuronal spiking activity that gives rise to the alpha oscillation in the thalamo-cortical system has been lacking. Here, we demonstrate how tACS entrains endogenous alpha oscillations in head-fixed awake ferrets. We first show that endogenous alpha oscillations in the posterior parietal cortex drive the primary visual cortex and the higher-order visual thalamus. Spike-field coherence is largest for the alpha frequency band, and presumed fast-spiking inhibitory interneurons exhibit strongest coupling to this oscillation. We then apply alpha-tACS that results in a field strength comparable to what is commonly used in humans (

Date: 2021
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DOI: 10.1038/s41467-021-23021-2

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