A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

Louciné Mitoyan, Véronique Chevrier, Hector Hernandez-Vargas, Alexane Ollivier, Zeinab Homayed, Julie Pannequin, Flora Poizat, Cécile Biasi-Cador, Emmanuelle Charafe-Jauffret, Christophe Ginestier and Géraldine Guasch ()
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Louciné Mitoyan: CRCM, Epithelial Stem Cells and Cancer Team
Véronique Chevrier: CRCM, Epithelial Stem Cells and Cancer Team
Hector Hernandez-Vargas: Université de Lyon, Centre Léon Bérard
Alexane Ollivier: CRCM, Epithelial Stem Cells and Cancer Team
Zeinab Homayed: Institut de Génomique Fonctionnelle
Julie Pannequin: Institut de Génomique Fonctionnelle
Flora Poizat: Institut Paoli-Calmettes
Cécile Biasi-Cador: Institut Paoli-Calmettes
Emmanuelle Charafe-Jauffret: CRCM, Epithelial Stem Cells and Cancer Team
Christophe Ginestier: CRCM, Epithelial Stem Cells and Cancer Team
Géraldine Guasch: CRCM, Epithelial Stem Cells and Cancer Team

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract At numerous locations of the body, transition zones are localized at the crossroad between two types of epithelium and are frequently associated with neoplasia involving both type of tissues. These transition zones contain cells expressing markers of adult stem cells that can be the target of early transformation. The mere fact that transition zone cells can merge different architecture with separate functions implies for a unique plasticity that these cells must display in steady state. However, their roles during tissue regeneration in normal and injured state remain unknown. Here, by using in vivo lineage tracing, single-cell transcriptomics, computational modeling and a three-dimensional organoid culture system of transition zone cells, we identify a population of Krt17+ basal cells with multipotent properties at the squamo-columnar anorectal junction that maintain a squamous epithelium during normal homeostasis and can participate in the repair of a glandular epithelium following tissue injury.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23034-x

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DOI: 10.1038/s41467-021-23034-x

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