Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries

Guy Berbers (), Pieter Gageldonk, Jan van de Kassteele, Ursula Wiedermann, Isabelle Desombere, Tine Dalby, Julie Toubiana, Sotirios Tsiodras, Ildikó Paluska Ferencz, Kathryn Mullan, Algirdas Griskevicius, Tatjana Kolupajeva, Didrik Frimann Vestrheim, Paula Palminha, Odette Popovici, Lena Wehlin, Tamara Kastrin, Lucia Maďarová, Helen Campbell, Csaba Ködmön, Sabrina Bacci, Alex-Mikael Barkoff and Qiushui He ()
Additional contact information
Guy Berbers: National Institute of Public Health and the Environment
Pieter Gageldonk: National Institute of Public Health and the Environment
Jan van de Kassteele: National Institute of Public Health and the Environment
Ursula Wiedermann: Medical University of Vienna
Isabelle Desombere: Sciensano, Public Health Belgium
Tine Dalby: Statens Serum Institut
Julie Toubiana: Institut Pasteur
Sotirios Tsiodras: Hellenic Center for Disease Control
Ildikó Paluska Ferencz: National Center for Epidemiology
Kathryn Mullan: National Virus reference laboratory
Algirdas Griskevicius: National Public Health Surveillance Laboratory
Tatjana Kolupajeva: Molecular Biology Department, NRL
Didrik Frimann Vestrheim: Norwegian Institute of Public Health
Paula Palminha: National Institute of Health
Odette Popovici: National Institute of Public Health
Lena Wehlin: Public Health Agency of Sweden
Tamara Kastrin: Slovenia National Laboratory of Health, Environment and Food
Lucia Maďarová: Regional Authority of Public Health
Helen Campbell: Public Health England
Csaba Ködmön: European Center for Disease Prevention and Control
Sabrina Bacci: European Center for Disease Prevention and Control
Alex-Mikael Barkoff: University of Turku
Qiushui He: University of Turku

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Reported incidence of pertussis in the European Union (EU) and the European Economic Area (EEA) varies and may not reflect the real situation, while vaccine-induced protection against diphtheria and tetanus seems sufficient. We aimed to determine the seroprevalence of DTP antibodies in EU/EEA countries within the age groups of 40–49 and 50–59 years. Eighteen countries collected around 500 samples between 2015 and 2018 (N = 10,302) which were analysed for IgG-DTP specific antibodies. The proportion of sera with pertussis toxin antibody levels ≥100 IU/mL, indicative of recent exposure to pertussis was comparable for 13/18 countries, ranging between 2.7–5.8%. For diphtheria the proportion of sera lacking the protective level (

Date: 2021
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DOI: 10.1038/s41467-021-23114-y

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