The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction

Fabiana Heredia, Yanel Volonté, Joana Pereirinha, Magdalena Fernandez-Acosta, Andreia P. Casimiro, Cláudia G. Belém, Filipe Viegas, Kohtaro Tanaka, Juliane Menezes, Maite Arana, Gisele A. Cardoso, André Macedo, Malwina Kotowicz, Facundo H. Prado Spalm, Marcos J. Dibo, Raquel D. Monfardini, Tatiana T. Torres, César S. Mendes, Andres Garelli () and Alisson M. Gontijo ()
Additional contact information
Fabiana Heredia: Universidade Nova de Lisboa
Yanel Volonté: Universidade Nova de Lisboa
Joana Pereirinha: Universidade Nova de Lisboa
Magdalena Fernandez-Acosta: Universidade Nova de Lisboa
Andreia P. Casimiro: Universidade Nova de Lisboa
Cláudia G. Belém: Universidade Nova de Lisboa
Filipe Viegas: Universidade Nova de Lisboa
Kohtaro Tanaka: Instituto Gulbenkian de Ciências
Juliane Menezes: Universidade Nova de Lisboa
Maite Arana: Universidad Nacional del Sur - CONICET
Gisele A. Cardoso: Universidade Nova de Lisboa
André Macedo: Universidade Nova de Lisboa
Malwina Kotowicz: Universidade Nova de Lisboa
Facundo H. Prado Spalm: Universidad Nacional del Sur - CONICET
Marcos J. Dibo: Universidad Nacional del Sur - CONICET
Raquel D. Monfardini: Universidade Nova de Lisboa
Tatiana T. Torres: Universidade de São Paulo
César S. Mendes: Universidade Nova de Lisboa
Andres Garelli: Universidade Nova de Lisboa
Alisson M. Gontijo: Universidade Nova de Lisboa

Nature Communications, 2021, vol. 12, issue 1, 1-20

Abstract: Abstract Innate behaviors consist of a succession of genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provide insight into these mechanisms by studying pupariation, a multi-step innate behavior of Drosophila larvae that is critical for survival during metamorphosis. We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Dilp8 acts on six Lgr3-positive thoracic interneurons to couple both subprograms in time and to instruct neuromotor subprogram switching during behavior. Our work reveals that interorgan feedback gates progression between subunits of an innate behavior and points to an ancestral neuromodulatory function of relaxin signaling.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23218-5

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DOI: 10.1038/s41467-021-23218-5

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