Mattertronics for programmable manipulation and multiplex storage of pseudo-diamagnetic holes and label-free cells

Sandhya Rani Goudu, Hyeonseol Kim, Xinghao Hu, Byeonghwa Lim, Kunwoo Kim, Sri Ramulu Torati, Hakan Ceylan, Devin Sheehan, Metin Sitti () and CheolGi Kim ()
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Sandhya Rani Goudu: Department of Emerging Materials Science, DGIST
Hyeonseol Kim: Department of Emerging Materials Science, DGIST
Xinghao Hu: Max Planck Institute for Intelligent Systems
Byeonghwa Lim: Department of Emerging Materials Science, DGIST
Kunwoo Kim: Department of Emerging Materials Science, DGIST
Sri Ramulu Torati: Department of Emerging Materials Science, DGIST
Hakan Ceylan: Max Planck Institute for Intelligent Systems
Devin Sheehan: Max Planck Institute for Intelligent Systems
Metin Sitti: Max Planck Institute for Intelligent Systems
CheolGi Kim: Department of Emerging Materials Science, DGIST

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Manipulating and separating single label-free cells without biomarker conjugation have attracted significant interest in the field of single-cell research, but digital circuitry control and multiplexed individual storage of single label-free cells remain a challenge. Herein, by analogy with the electrical circuitry elements and electronical holes, we develop a pseudo-diamagnetophoresis (PsD) mattertronic approach in the presence of biocompatible ferrofluids for programmable manipulation and local storage of single PsD holes and label-free cells. The PsD holes conduct along linear negative micro-magnetic patterns. Further, eclipse diode patterns similar to the electrical diode can implement directional and selective switching of different PsD holes and label-free cells based on the diode geometry. Different eclipse heights and junction gaps influence the switching efficiency of PsD holes for mattertronic circuitry manipulation and separation. Moreover, single PsD holes are stored at each potential well as in an electrical storage capacitor, preventing multiple occupancies of PsD holes in the array of individual compartments due to magnetic Coulomb-like interaction. This approach may enable the development of large programmable arrays of label-free matters with high throughput, efficiency, and reliability as multiplex cell research platforms.

Date: 2021
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DOI: 10.1038/s41467-021-23251-4

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