Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa

Ben Morton (), Kayla G. Barnes, Catherine Anscombe, Khuzwayo Jere, Prisca Matambo, Jonathan Mandolo, Raphael Kamng’ona, Comfort Brown, James Nyirenda, Tamara Phiri, Ndaziona P. Banda, Charlotte Van Der Veer, Kwazizira S. Mndolo, Kelvin Mponda, Jamie Rylance, Chimota Phiri, Jane Mallewa, Mulinda Nyirenda, Grace Katha, Paul Kambiya, James Jafali, Henry C. Mwandumba, Stephen B. Gordon, Jennifer Cornick and Kondwani C. Jambo ()
Additional contact information
Ben Morton: University of Malawi College of Medicine
Kayla G. Barnes: University of Malawi College of Medicine
Catherine Anscombe: University of Malawi College of Medicine
Khuzwayo Jere: University of Malawi College of Medicine
Prisca Matambo: University of Malawi College of Medicine
Jonathan Mandolo: University of Malawi College of Medicine
Raphael Kamng’ona: University of Malawi College of Medicine
Comfort Brown: University of Malawi College of Medicine
James Nyirenda: University of Malawi College of Medicine
Tamara Phiri: Queen Elizabeth Central Hospital
Ndaziona P. Banda: University of Malawi-College of Medicine
Charlotte Van Der Veer: University of Malawi College of Medicine
Kwazizira S. Mndolo: Queen Elizabeth Central Hospital
Kelvin Mponda: Queen Elizabeth Central Hospital
Jamie Rylance: University of Malawi College of Medicine
Chimota Phiri: Queen Elizabeth Central Hospital
Jane Mallewa: University of Malawi-College of Medicine
Mulinda Nyirenda: University of Malawi-College of Medicine
Grace Katha: Queen Elizabeth Central Hospital
Paul Kambiya: University of Malawi College of Medicine
James Jafali: University of Malawi College of Medicine
Henry C. Mwandumba: University of Malawi College of Medicine
Stephen B. Gordon: University of Malawi College of Medicine
Jennifer Cornick: University of Malawi College of Medicine
Kondwani C. Jambo: University of Malawi College of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract Although the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, and healthy community controls (PCR-negative/IgG-negative). PCR-positive COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-negative/IgG-positive and PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants exhibited a nasal and systemic cytokine signature analogous to PCR-positive COVID-19 participants, predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants had increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. PCR-negative/IgG-positive individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23267-w

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DOI: 10.1038/s41467-021-23267-w

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