Club cell-specific role of programmed cell death 5 in pulmonary fibrosis

Soo-Yeon Park, Jung Yeon Hong, Soo Yeon Lee, Seung-Hyun Lee, Mi Jeong Kim, Soo Yeon Kim, Kyung Won Kim, Hyo Sup Shim, Moo Suk Park, Chun Geun Lee, Jack A. Elias, Myung Hyun Sohn () and Ho-Geun Yoon ()
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Soo-Yeon Park: Yonsei University College of Medicine
Jung Yeon Hong: Yonsei University College of Medicine
Soo Yeon Lee: Yonsei University College of Medicine
Seung-Hyun Lee: Yonsei University College of Medicine
Mi Jeong Kim: Yonsei University College of Medicine
Soo Yeon Kim: Yonsei University College of Medicine
Kyung Won Kim: Yonsei University College of Medicine
Hyo Sup Shim: Yonsei University College of Medicine
Moo Suk Park: Yonsei University College of Medicine
Chun Geun Lee: Brown University
Jack A. Elias: Brown University
Myung Hyun Sohn: Yonsei University College of Medicine
Ho-Geun Yoon: Yonsei University College of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibrosis is significantly diminished by club cell-specific deletion of Pdcd5 gene. PDCD5 mediates β-catenin/Smad3 complex formation, promoting TGF-β-induced transcriptional activation of matricellular genes. Club cell Pdcd5 knockdown reduces matricellular protein secretion, inhibiting fibroblast proliferation and collagen synthesis. Here, we demonstrate the club cell-specific role of PDCD5 as a mediator of lung fibrosis and potential therapeutic target for IPF.

Date: 2021
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DOI: 10.1038/s41467-021-23277-8

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