Hox dosage contributes to flight appendage morphology in Drosophila

Rachel Paul, Guillaume Giraud, Katrin Domsch, Marilyne Duffraisse, Frédéric Marmigère, Soumen Khan, Solene Vanderperre, Ingrid Lohmann, Robby Stoks, L. S. Shashidhara and Samir Merabet ()
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Rachel Paul: IGFL, CNRS UMR5242, ENS Lyon
Guillaume Giraud: IGFL, CNRS UMR5242, ENS Lyon
Katrin Domsch: University of Heidelberg, Centre for Organismal Studies (COS) Heidelberg Department of Developmental Biology
Marilyne Duffraisse: IGFL, CNRS UMR5242, ENS Lyon
Frédéric Marmigère: IGFL, CNRS UMR5242, ENS Lyon
Soumen Khan: Indian Institute of Science Education and Research (IISER)
Solene Vanderperre: IGFL, CNRS UMR5242, ENS Lyon
Ingrid Lohmann: University of Heidelberg, Centre for Organismal Studies (COS) Heidelberg Department of Developmental Biology
Robby Stoks: Evolution and Conservation
L. S. Shashidhara: Indian Institute of Science Education and Research (IISER)
Samir Merabet: IGFL, CNRS UMR5242, ENS Lyon

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Flying insects have invaded all the aerial space on Earth and this astonishing radiation could not have been possible without a remarkable morphological diversification of their flight appendages. Here, we show that characteristic spatial expression profiles and levels of the Hox genes Antennapedia (Antp) and Ultrabithorax (Ubx) underlie the formation of two different flight organs in the fruit fly Drosophila melanogaster. We further demonstrate that flight appendage morphology is dependent on specific Hox doses. Interestingly, we find that wing morphology from evolutionary distant four-winged insect species is also associated with a differential expression of Antp and Ubx. We propose that variation in the spatial expression profile and dosage of Hox proteins is a major determinant of flight appendage diversification in Drosophila and possibly in other insect species during evolution.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23293-8

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DOI: 10.1038/s41467-021-23293-8

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