Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles

Jiang-Fei Li, Wei-Wei Xu, Rong-Hua Wang, Yue Li, Ge Yin and Mengchun Ye ()
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Jiang-Fei Li: Nankai University
Wei-Wei Xu: Nankai University
Rong-Hua Wang: Nankai University
Yue Li: Nankai University
Ge Yin: Nankai University
Mengchun Ye: Nankai University

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract The construction of 7-membered ring via direct C7–H cyclization of benzoimidazoles with alkenes would provide a more atom- and step-economical route to tricyclic imidazoles and derivatives that widely exist in a broad range of bioactive molecules. However, transition metal-catalyzed C–H cyclization for medium-ring synthesis has been limited to reactive C–H bonds, instead, the activation of unreactive C–H bonds towards medium synthesis still remains an elusive challenge. Herein, we report a direct construction of 7-membered rings via Ni–Al co-catalyzed unreactive C7–H cyclization of benzoimidazoles with alkenes, providing a series of tricyclic imidazoles in 40–98% yield and with up to 95:5 er.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23371-x

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DOI: 10.1038/s41467-021-23371-x

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