Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa

Ernest Diez Benavente, Emilia Manko, Jody Phelan, Monica Campos, Debbie Nolder, Diana Fernandez, Gabriel Velez-Tobon, Alberto Tobón Castaño, Jamille G. Dombrowski, Claudio R. F. Marinho, Anna Caroline C. Aguiar, Dhelio Batista Pereira, Kanlaya Sriprawat, Francois Nosten, Robert Moon, Colin J. Sutherland, Susana Campino () and Taane G. Clark ()
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Ernest Diez Benavente: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
Emilia Manko: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
Jody Phelan: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
Monica Campos: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
Debbie Nolder: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
Diana Fernandez: Grupo Malaria, Facultad de Medicina, Universidad de Antioquia
Gabriel Velez-Tobon: Grupo Malaria, Facultad de Medicina, Universidad de Antioquia
Alberto Tobón Castaño: Grupo Malaria, Facultad de Medicina, Universidad de Antioquia
Jamille G. Dombrowski: Institute of Biomedical Sciences, University of São Paulo
Claudio R. F. Marinho: Institute of Biomedical Sciences, University of São Paulo
Anna Caroline C. Aguiar: Institute of Biomedical Sciences, University of São Paulo
Dhelio Batista Pereira: Research Center for Tropical Medicine of Rondonia
Kanlaya Sriprawat: Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
Francois Nosten: Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
Robert Moon: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
Colin J. Sutherland: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
Susana Campino: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
Taane G. Clark: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Despite the high burden of Plasmodium vivax malaria in South Asian countries, the genetic diversity of circulating parasite populations is not well described. Determinants of antimalarial drug susceptibility for P. vivax in the region have not been characterised. Our genomic analysis of global P. vivax (n = 558) establishes South Asian isolates (n = 92) as a distinct subpopulation, which shares ancestry with some East African and South East Asian parasites. Signals of positive selection are linked to drug resistance-associated loci including pvkelch10, pvmrp1, pvdhfr and pvdhps, and two loci linked to P. vivax invasion of reticulocytes, pvrbp1a and pvrbp1b. Significant identity-by-descent was found in extended chromosome regions common to P. vivax from India and Ethiopia, including the pvdbp gene associated with Duffy blood group binding. Our investigation provides new understanding of global P. vivax population structure and genomic diversity, and genetic evidence of recent directional selection in this important human pathogen.

Date: 2021
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DOI: 10.1038/s41467-021-23422-3

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