The SUN1-SPDYA interaction plays an essential role in meiosis prophase I

Yanyan Chen, Yan Wang, Juan Chen, Wu Zuo, Yong Fan, Sijia Huang, Yongmei Liu, Guangming Chen, Qing Li, Jinsong Li, Jian Wu, Qian Bian, Chenhui Huang () and Ming Lei ()
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Yanyan Chen: Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Yan Wang: Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Juan Chen: Shanghai Jiao Tong University School of Medicine
Wu Zuo: Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Yong Fan: Shanghai Jiao Tong University School of Medicine
Sijia Huang: Shanghai Jiao Tong University School of Medicine
Yongmei Liu: Shanghai Jiao Tong University School of Medicine
Guangming Chen: Shanghai Jiao Tong University School of Medicine
Qing Li: University of Chinese Academy of Sciences
Jinsong Li: University of Chinese Academy of Sciences
Jian Wu: Shanghai Jiao Tong University School of Medicine
Qian Bian: Shanghai Jiao Tong University School of Medicine
Chenhui Huang: Shanghai Jiao Tong University School of Medicine
Ming Lei: Shanghai Jiao Tong University School of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract Chromosomes pair and synapse with their homologous partners to segregate correctly at the first meiotic division. Association of telomeres with the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex composed of SUN1 and KASH5 enables telomere-led chromosome movements and telomere bouquet formation, facilitating precise pairwise alignment of homologs. Here, we identify a direct interaction between SUN1 and Speedy A (SPDYA) and determine the crystal structure of human SUN1-SPDYA-CDK2 ternary complex. Analysis of meiosis prophase I process in SPDYA-binding-deficient SUN1 mutant mice reveals that the SUN1-SPDYA interaction is required for the telomere-LINC complex connection and the assembly of a ring-shaped telomere supramolecular architecture at the nuclear envelope, which is critical for efficient homologous pairing and synapsis. Overall, our results provide structural insights into meiotic telomere structure that is essential for meiotic prophase I progression.

Date: 2021
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DOI: 10.1038/s41467-021-23550-w

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