A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription

Long Jin, Qianzi Tang (), Silu Hu, Zhongxu Chen, Xuming Zhou, Bo Zeng, Yuhao Wang, Mengnan He, Yan Li, Lixuan Gui, Linyuan Shen, Keren Long, Jideng Ma, Xun Wang, Zhengli Chen, Yanzhi Jiang, Guoqing Tang, Li Zhu, Fei Liu, Bo Zhang, Zhiqing Huang, Guisen Li, Diyan Li, Vadim N. Gladyshev, Jingdong Yin, Yiren Gu, Xuewei Li and Mingzhou Li ()
Additional contact information
Long Jin: Sichuan Agricultural University
Qianzi Tang: Sichuan Agricultural University
Silu Hu: Sichuan Agricultural University
Zhongxu Chen: Tcuni Inc.
Xuming Zhou: Chinese Academy of Sciences
Bo Zeng: Sichuan Agricultural University
Yuhao Wang: Sichuan Agricultural University
Mengnan He: Sichuan Agricultural University
Yan Li: Sichuan Agricultural University
Lixuan Gui: Tcuni Inc.
Linyuan Shen: Sichuan Agricultural University
Keren Long: Sichuan Agricultural University
Jideng Ma: Sichuan Agricultural University
Xun Wang: Sichuan Agricultural University
Zhengli Chen: Sichuan Agricultural University
Yanzhi Jiang: Sichuan Agricultural University
Guoqing Tang: Sichuan Agricultural University
Li Zhu: Sichuan Agricultural University
Fei Liu: Sichuan Agricultural University
Bo Zhang: Ya’an Digital Economy Operation Company
Zhiqing Huang: Sichuan Agricultural University
Guisen Li: Sichuan Provincial People’s Hospital
Diyan Li: Sichuan Agricultural University
Vadim N. Gladyshev: Brigham and Women’s Hospital
Jingdong Yin: China Agricultural University
Yiren Gu: Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal Science Academy
Xuewei Li: Sichuan Agricultural University
Mingzhou Li: Sichuan Agricultural University

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract A comprehensive transcriptomic survey of pigs can provide a mechanistic understanding of tissue specialization processes underlying economically valuable traits and accelerate their use as a biomedical model. Here we characterize four transcript types (lncRNAs, TUCPs, miRNAs, and circRNAs) and protein-coding genes in 31 adult pig tissues and two cell lines. We uncover the transcriptomic variability among 47 skeletal muscles, and six adipose depots linked to their different origins, metabolism, cell composition, physical activity, and mitochondrial pathways. We perform comparative analysis of the transcriptomes of seven tissues from pigs and nine other vertebrates to reveal that evolutionary divergence in transcription potentially contributes to lineage-specific biology. Long-range promoter–enhancer interaction analysis in subcutaneous adipose tissues across species suggests evolutionarily stable transcription patterns likely attributable to redundant enhancers buffering gene expression patterns against perturbations, thereby conferring robustness during speciation. This study can facilitate adoption of the pig as a biomedical model for human biology and disease and uncovers the molecular bases of valuable traits.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23560-8

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DOI: 10.1038/s41467-021-23560-8

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