Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes

Maysam Mansouri, Marie-Didiée Hussherr, Tobias Strittmatter, Peter Buchmann, Shuai Xue, Gieri Camenisch and Martin Fussenegger ()
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Maysam Mansouri: ETH Zurich
Marie-Didiée Hussherr: ETH Zurich
Tobias Strittmatter: ETH Zurich
Peter Buchmann: ETH Zurich
Shuai Xue: ETH Zurich
Gieri Camenisch: ETH Zurich
Martin Fussenegger: ETH Zurich

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract Wearable smart electronic devices, such as smart watches, are generally equipped with green-light-emitting diodes, which are used for photoplethysmography to monitor a panoply of physical health parameters. Here, we present a traceless, green-light-operated, smart-watch-controlled mammalian gene switch (Glow Control), composed of an engineered membrane-tethered green-light-sensitive cobalamin-binding domain of Thermus thermophilus (TtCBD) CarH protein in combination with a synthetic cytosolic TtCBD-transactivator fusion protein, which manage translocation of TtCBD-transactivator into the nucleus to trigger expression of transgenes upon illumination. We show that Apple-Watch-programmed percutaneous remote control of implanted Glow-controlled engineered human cells can effectively treat experimental type-2 diabetes by producing and releasing human glucagon-like peptide-1 on demand. Directly interfacing wearable smart electronic devices with therapeutic gene expression will advance next-generation personalized therapies by linking biopharmaceutical interventions to the internet of things.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23572-4

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DOI: 10.1038/s41467-021-23572-4

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