Tumor suppressor p53 regulates intestinal type 2 immunity

Chun-Yuan Chang, Jianming Wang, Yuhan Zhao, Juan Liu, Xue Yang, Xuetian Yue, Huaying Wang, Fan Zhou, Juan M. Inclan-Rico, John J. Ponessa, Ping Xie, Lanjing Zhang, Mark C. Siracusa, Zhaohui Feng () and Wenwei Hu ()
Additional contact information
Chun-Yuan Chang: Rutgers Cancer Institute of New Jersey, Rutgers University
Jianming Wang: Rutgers Cancer Institute of New Jersey, Rutgers University
Yuhan Zhao: Rutgers Cancer Institute of New Jersey, Rutgers University
Juan Liu: Rutgers Cancer Institute of New Jersey, Rutgers University
Xue Yang: Rutgers Cancer Institute of New Jersey, Rutgers University
Xuetian Yue: Rutgers Cancer Institute of New Jersey, Rutgers University
Huaying Wang: Rutgers Cancer Institute of New Jersey, Rutgers University
Fan Zhou: Rutgers Cancer Institute of New Jersey, Rutgers University
Juan M. Inclan-Rico: Rutgers New Jersey Medical School, Rutgers University
John J. Ponessa: Rutgers New Jersey Medical School, Rutgers University
Ping Xie: Rutgers University
Lanjing Zhang: Rutgers Cancer Institute of New Jersey, Rutgers University
Mark C. Siracusa: Rutgers New Jersey Medical School, Rutgers University
Zhaohui Feng: Rutgers Cancer Institute of New Jersey, Rutgers University
Wenwei Hu: Rutgers Cancer Institute of New Jersey, Rutgers University

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract The role of p53 in tumor suppression has been extensively studied and well-established. However, the role of p53 in parasitic infections and the intestinal type 2 immunity is unclear. Here, we report that p53 is crucial for intestinal type 2 immunity in response to the infection of parasites, such as Tritrichomonas muris and Nippostrongylus brasiliensis. Mechanistically, p53 plays a critical role in the activation of the tuft cell-IL-25-type 2 innate lymphoid cell circuit, partly via transcriptional regulation of Lrmp in tuft cells. Lrmp modulates Ca2+ influx and IL-25 release, which are critical triggers of type 2 innate lymphoid cell response. Our results thus reveal a previously unrecognized function of p53 in regulating intestinal type 2 immunity to protect against parasitic infections, highlighting the role of p53 as a guardian of immune integrity.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-23587-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23587-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-23587-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().