RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection

Kemal Avican (), Jehad Aldahdooh, Matteo Togninalli, A. K. M. Firoj Mahmud, Jing Tang, Karsten M. Borgwardt, Mikael Rhen and Maria Fällman ()
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Kemal Avican: Umeå University
Jehad Aldahdooh: University of Helsinki
Matteo Togninalli: ETH Zürich
A. K. M. Firoj Mahmud: Umeå University
Jing Tang: University of Helsinki
Karsten M. Borgwardt: ETH Zürich
Mikael Rhen: Karolinska Institute
Maria Fällman: Umeå University

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Bacterial processes necessary for adaption to stressful host environments are potential targets for new antimicrobials. Here, we report large-scale transcriptomic analyses of 32 human bacterial pathogens grown under 11 stress conditions mimicking human host environments. The potential relevance of the in vitro stress conditions and responses is supported by comparisons with available in vivo transcriptomes of clinically important pathogens. Calculation of a probability score enables comparative cross-microbial analyses of the stress responses, revealing common and unique regulatory responses to different stresses, as well as overlapping processes participating in different stress responses. We identify conserved and species-specific ‘universal stress responders’, that is, genes showing altered expression in multiple stress conditions. Non-coding RNAs are involved in a substantial proportion of the responses. The data are collected in a freely available, interactive online resource (PATHOgenex).

Date: 2021
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DOI: 10.1038/s41467-021-23588-w

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