Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting

Jifeng Liu, Hongyan Long, Dagmar Zeuschner, Andreas F. B. Räder, William J. Polacheck, Horst Kessler, Lydia Sorokin and Britta Trappmann ()
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Jifeng Liu: Bioactive Materials Laboratory, Max Planck Institute for Molecular Biomedicine
Hongyan Long: Bioactive Materials Laboratory, Max Planck Institute for Molecular Biomedicine
Dagmar Zeuschner: Electron Microscopy Unit, Max Planck Institute for Molecular Biomedicine
Andreas F. B. Räder: Technical University of Munich
William J. Polacheck: University of North Carolina at Chapel Hill and North Carolina State University
Horst Kessler: Technical University of Munich
Lydia Sorokin: University of Münster
Britta Trappmann: Bioactive Materials Laboratory, Max Planck Institute for Molecular Biomedicine

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract A major deficit in tissue engineering strategies is the lack of materials that promote angiogenesis, wherein endothelial cells from the host vasculature invade the implanted matrix to form new blood vessels. To determine the material properties that regulate angiogenesis, we have developed a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens. We show that long, perfusable tubes only develop if hydrogel adhesiveness and degradability are fine-tuned to support the initial collective invasion of endothelial cells and, at the same time, allow for matrix remodeling to permit the opening of lumens. These studies provide a better understanding of how cell-matrix interactions regulate angiogenesis and, therefore, constitute an important step towards optimal design criteria for tissue-engineered materials that require vascularization.

Date: 2021
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DOI: 10.1038/s41467-021-23644-5

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