Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination

Bowen Yang, Heliang Yao, Han Tian, Zhiguo Yu, Yuedong Guo, Yuemei Wang, Jiacai Yang, Chang Chen and Jianlin Shi ()
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Bowen Yang: Chinese Academy of Sciences
Heliang Yao: Chinese Academy of Sciences
Han Tian: Chinese Academy of Sciences
Zhiguo Yu: Chinese Academy of Sciences
Yuedong Guo: Chinese Academy of Sciences
Yuemei Wang: Chinese Academy of Sciences
Jiacai Yang: Chinese Academy of Sciences
Chang Chen: Chinese Academy of Sciences
Jianlin Shi: Chinese Academy of Sciences

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract The iron gall ink-triggered chemical corrosion of hand-written documents is a big threat to Western cultural heritages, which was demonstrated to result from the iron gall (GA-Fe) chelate-promoted reactive oxygen species generation. Such a phenomenon has inspired us to apply the pro-oxidative mechanism of GA-Fe to anticancer therapy. In this work, we construct a composite cancer nanomedicine by loading gallate into a Fe-engineered mesoporous silica nanocarrier, which can degrade in acidic tumor to release the doped Fe3+ and the loaded gallate, forming GA-Fe nanocomplex in situ. The nanocomplex with a highly reductive ligand field can promote oxygen reduction reactions generating hydrogen peroxide. Moreover, the resultant two-electron oxidation form of GA-Fe is an excellent Fenton-like agent that can catalyze hydrogen peroxide decomposition into hydroxyl radical, finally triggering severe oxidative damage to tumors. Such a therapeutic approach by intratumoral synthesis of GA-Fe nano-metalchelate may be instructive to future anticancer researches.

Date: 2021
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DOI: 10.1038/s41467-021-23710-y

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