Glucose-oxidase like catalytic mechanism of noble metal nanozymes

Jinxing Chen, Qian Ma, Minghua Li, Daiyong Chao, Liang Huang, Weiwei Wu, Youxing Fang () and Shaojun Dong ()
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Jinxing Chen: Chinese Academy of Sciences
Qian Ma: Chinese Academy of Sciences
Minghua Li: Chinese Academy of Sciences
Daiyong Chao: Chinese Academy of Sciences
Liang Huang: Chinese Academy of Sciences
Weiwei Wu: Chinese Academy of Sciences
Youxing Fang: Chinese Academy of Sciences
Shaojun Dong: Chinese Academy of Sciences

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Au nanoparticles (NPs) have been found to be excellent glucose oxidase mimics, while the catalytic processes have rarely been studied. Here, we reveal that the process of glucose oxidation catalyzed by Au NPs is as the same as that of natural glucose oxidase, namely, a two-step reaction including the dehydrogenation of glucose and the subsequent reduction of O2 to H2O2 by two electrons. Pt, Pd, Ru, Rh, and Ir NPs can also catalyze the dehydrogenation of glucose, except that O2 is preferably reduced to H2O. By the electron transfer feature of noble metal NPs, we overcame the limitation that H2O2 must be produced in the traditional two-step glucose assay and realize the rapid colorimetric detections of glucose. Inspired by the electron transport pathway in the catalytic process of natural enzymes, noble metal NPs have also been found to mimic various enzymatic electron transfer reactions including cytochrome c, coenzymes as well as nitrobenzene reductions.

Date: 2021
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DOI: 10.1038/s41467-021-23737-1

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