Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations

Nicholas C. Cullen, Antoine Leuzy, Shorena Janelidze, Sebastian Palmqvist, Anna L. Svenningsson, Erik Stomrud, Jeffrey L. Dage, Niklas Mattsson-Carlgren () and Oskar Hansson ()
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Nicholas C. Cullen: Lund University
Antoine Leuzy: Lund University
Shorena Janelidze: Lund University
Sebastian Palmqvist: Lund University
Anna L. Svenningsson: Lund University
Erik Stomrud: Lund University
Jeffrey L. Dage: Eli Lilly and Company
Niklas Mattsson-Carlgren: Lund University
Oskar Hansson: Lund University

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Plasma biomarkers of amyloid, tau, and neurodegeneration (ATN) need to be characterized in cognitively unimpaired (CU) elderly individuals. We therefore tested if plasma measurements of amyloid-β (Aβ)42/40, phospho-tau217 (P-tau217), and neurofilament light (NfL) together predict clinical deterioration in 435 CU individuals followed for an average of 4.8 ± 1.7 years in the BioFINDER study. A combination of all three plasma biomarkers and basic demographics best predicted change in cognition (Pre-Alzheimer’s Clinical Composite; R2 = 0.14, 95% CI [0.12–0.17]; P

Date: 2021
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DOI: 10.1038/s41467-021-23746-0

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