Geometrically encoded SERS nanobarcodes for the logical detection of nasopharyngeal carcinoma-related progression biomarkers

Duo Lin, Chang-Lin Hsieh, Keng-Chia Hsu, Pei-Hsuan Liao, Sufang Qiu, Tianxun Gong, Ken-Tye Yong, Shangyuan Feng and Kien Voon Kong ()
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Duo Lin: Fujian Normal University
Chang-Lin Hsieh: National Taiwan University
Keng-Chia Hsu: National Taiwan University
Pei-Hsuan Liao: National Taiwan University
Sufang Qiu: Fujian Medical University Cancer Hospital, Fujian Cancer Hospital
Tianxun Gong: University of Electronic Science and Technology of China
Ken-Tye Yong: The University of Sydney
Shangyuan Feng: Fujian Normal University
Kien Voon Kong: National Taiwan University

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract The limited availability of nasopharyngeal carcinoma-related progression biomarker array kits that offer physicians comprehensive information is disadvantageous for monitoring cancer progression. To develop a biomarker array kit, systematic identification and differentiation of a large number of distinct molecular surface-enhanced Raman scattering (SERS) reporters with high spectral temporal resolution is a major challenge. To address this unmet need, we use the chemistry of metal carbonyls to construct a series of unique SERS reporters with the potential to provide logical and highly multiplex information during testing. In this study, we report that geometric control over metal carbonyls on nanotags can produce 14 distinct barcodes that can be decoded unambiguously using commercial Raman spectroscopy. These metal carbonyl nanobarcodes are tested on human blood samples and show strong sensitivity (0.07 ng/mL limit of detection, average CV of 6.1% and >92% degree of recovery) and multiplexing capabilities for MMPs.

Date: 2021
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DOI: 10.1038/s41467-021-23789-3

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