SARS-CoV-2 infection and transmission in the North American deer mouse

Bryan D. Griffin, Mable Chan, Nikesh Tailor, Emelissa J. Mendoza, Anders Leung, Bryce M. Warner, Ana T. Duggan, Estella Moffat, Shihua He, Lauren Garnett, Kaylie N. Tran, Logan Banadyga, Alixandra Albietz, Kevin Tierney, Jonathan Audet, Alexander Bello, Robert Vendramelli, Amrit S. Boese, Lisa Fernando, L. Robbin Lindsay, Claire M. Jardine, Heidi Wood, Guillaume Poliquin, James E. Strong, Michael Drebot, David Safronetz, Carissa Embury-Hyatt and Darwyn Kobasa ()
Additional contact information
Bryan D. Griffin: National Microbiology Laboratory, Public Health Agency of Canada
Mable Chan: National Microbiology Laboratory, Public Health Agency of Canada
Nikesh Tailor: National Microbiology Laboratory, Public Health Agency of Canada
Emelissa J. Mendoza: National Microbiology Laboratory, Public Health Agency of Canada
Anders Leung: National Microbiology Laboratory, Public Health Agency of Canada
Bryce M. Warner: National Microbiology Laboratory, Public Health Agency of Canada
Ana T. Duggan: National Microbiology Laboratory, Public Health Agency of Canada
Estella Moffat: Canadian Food Inspection Agency
Shihua He: National Microbiology Laboratory, Public Health Agency of Canada
Lauren Garnett: National Microbiology Laboratory, Public Health Agency of Canada
Kaylie N. Tran: National Microbiology Laboratory, Public Health Agency of Canada
Logan Banadyga: National Microbiology Laboratory, Public Health Agency of Canada
Alixandra Albietz: National Microbiology Laboratory, Public Health Agency of Canada
Kevin Tierney: National Microbiology Laboratory, Public Health Agency of Canada
Jonathan Audet: National Microbiology Laboratory, Public Health Agency of Canada
Alexander Bello: National Microbiology Laboratory, Public Health Agency of Canada
Robert Vendramelli: National Microbiology Laboratory, Public Health Agency of Canada
Amrit S. Boese: National Microbiology Laboratory, Public Health Agency of Canada
Lisa Fernando: National Microbiology Laboratory, Public Health Agency of Canada
L. Robbin Lindsay: National Microbiology Laboratory, Public Health Agency of Canada
Claire M. Jardine: University of Guelph
Heidi Wood: National Microbiology Laboratory, Public Health Agency of Canada
Guillaume Poliquin: University of Manitoba
James E. Strong: National Microbiology Laboratory, Public Health Agency of Canada
Michael Drebot: National Microbiology Laboratory, Public Health Agency of Canada
David Safronetz: National Microbiology Laboratory, Public Health Agency of Canada
Carissa Embury-Hyatt: Canadian Food Inspection Agency
Darwyn Kobasa: National Microbiology Laboratory, Public Health Agency of Canada

Nature Communications, 2021, vol. 12, issue 1, 1-10

Abstract: Abstract Widespread circulation of SARS-CoV-2 in humans raises the theoretical risk of reverse zoonosis events with wildlife, reintroductions of SARS-CoV-2 into permissive nondomesticated animals. Here we report that North American deer mice (Peromyscus maniculatus) are susceptible to SARS-CoV-2 infection following intranasal exposure to a human isolate, resulting in viral replication in the upper and lower respiratory tract with little or no signs of disease. Further, shed infectious virus is detectable in nasal washes, oropharyngeal and rectal swabs, and viral RNA is detectable in feces and occasionally urine. We further show that deer mice are capable of transmitting SARS-CoV-2 to naïve deer mice through direct contact. The extent to which these observations may translate to wild deer mouse populations remains unclear, and the risk of reverse zoonosis and/or the potential for the establishment of Peromyscus rodents as a North American reservoir for SARS-CoV-2 remains unknown.

Date: 2021
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DOI: 10.1038/s41467-021-23848-9

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