A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

Min-A Jhun (), Michael Mendelson, Rory Wilson, Rahul Gondalia, Roby Joehanes, Elias Salfati, Xiaoping Zhao, Kim Valeska Emilie Braun, Anh Nguyet Do, Åsa K. Hedman, Tao Zhang, Elena Carnero-Montoro, Jincheng Shen, Traci M. Bartz, Jennifer A. Brody, May E. Montasser, Jeff R. O’Connell, Chen Yao, Rui Xia, Eric Boerwinkle, Megan Grove, Weihua Guan, Pfeiffer Liliane, Paula Singmann, Martina Müller-Nurasyid, Thomas Meitinger, Christian Gieger, Annette Peters, Wei Zhao, Erin B. Ware, Jennifer A. Smith, Klodian Dhana, Joyce Meurs, Andre Uitterlinden, Mohammad Arfan Ikram, Mohsen Ghanbari, Deugi Zhi, Stefan Gustafsson, Lars Lind, Shengxu Li, Dianjianyi Sun, Tim D. Spector, Yii- der Ida Chen, Coleen Damcott, Alan R. Shuldiner, Devin M. Absher, Steve Horvath, Philip S. Tsao, Sharon Kardia, Bruce M. Psaty, Nona Sotoodehnia, Jordana T. Bell, Erik Ingelsson, Wei Chen, Abbas Dehghan, Donna K. Arnett, Melanie Waldenberger, Lifang Hou, Eric A. Whitsel, Andrea Baccarelli, Daniel Levy, Myriam Fornage, Marguerite R. Irvin and Themistocles L. Assimes ()
Additional contact information
Min-A Jhun: University of Michigan School of Public Health
Michael Mendelson: National Institutes of Health
Rory Wilson: Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Rahul Gondalia: University of North Carolina
Roby Joehanes: Harvard Medical School
Elias Salfati: Stanford University School of Medicine
Xiaoping Zhao: The University of Texas Health Science Center at Houston
Kim Valeska Emilie Braun: Erasmus MC University Medical Center
Anh Nguyet Do: University of Alabama at Birmingham
Åsa K. Hedman: Uppsala University
Tao Zhang: Tulane University School of Public Health and Tropical Medicine
Elena Carnero-Montoro: King’s College London
Jincheng Shen: University of Utah
Traci M. Bartz: University of Washington
Jennifer A. Brody: University of Washington
May E. Montasser: University of Maryland School of Medicine
Jeff R. O’Connell: University of Maryland School of Medicine
Chen Yao: National Institutes of Health
Rui Xia: The University of Texas Health Science Center at Houston
Eric Boerwinkle: University of Texas Health Science Center at Houston
Megan Grove: University of Texas Health Science Center at Houston
Weihua Guan: University of Minnesota
Pfeiffer Liliane: Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Paula Singmann: Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Martina Müller-Nurasyid: Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Thomas Meitinger: Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University
Christian Gieger: Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Annette Peters: Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Wei Zhao: University of Michigan School of Public Health
Erin B. Ware: University of Michigan School of Public Health
Jennifer A. Smith: University of Michigan School of Public Health
Klodian Dhana: Rush University Medical Center
Joyce Meurs: Erasmus MC University Medical Center
Andre Uitterlinden: Erasmus MC University Medical Center
Mohammad Arfan Ikram: Erasmus MC University Medical Center
Mohsen Ghanbari: Erasmus MC University Medical Center
Deugi Zhi: University of Texas Health Science Center at Houston
Stefan Gustafsson: Uppsala University
Lars Lind: Uppsala University
Shengxu Li: Tulane University School of Public Health and Tropical Medicine
Dianjianyi Sun: Tulane University School of Public Health and Tropical Medicine
Tim D. Spector: King’s College London
Yii- der Ida Chen: Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, and Department of Pediatrics, Harbor-UCLA Medical Center
Coleen Damcott: University of Maryland School of Medicine
Alan R. Shuldiner: University of Maryland School of Medicine
Devin M. Absher: HudsonAlpha Institute for Biotechnology
Steve Horvath: University of California Los Angeles
Philip S. Tsao: Stanford University School of Medicine
Sharon Kardia: University of Michigan School of Public Health
Bruce M. Psaty: University of Washington
Nona Sotoodehnia: University of Washington
Jordana T. Bell: King’s College London
Erik Ingelsson: Stanford University School of Medicine
Wei Chen: Tulane University School of Public Health and Tropical Medicine
Abbas Dehghan: Erasmus MC University Medical Center
Donna K. Arnett: University of Alabama at Birmingham
Melanie Waldenberger: Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Lifang Hou: Northwestern University
Eric A. Whitsel: University of North Carolina
Andrea Baccarelli: Department of Environmental Health Sciences, Harvard T.H. Chan School of Public Health
Daniel Levy: National Institutes of Health
Myriam Fornage: The University of Texas Health Science Center at Houston
Marguerite R. Irvin: University of Alabama at Birmingham
Themistocles L. Assimes: Stanford University School of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups.

Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-23899-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23899-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-23899-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().