Single cell derived mRNA signals across human kidney tumors

Matthew D. Young (), Thomas J. Mitchell, Lars Custers, Thanasis Margaritis, Francisco Morales-Rodriguez, Kwasi Kwakwa, Eleonora Khabirova, Gerda Kildisiute, Thomas R. W. Oliver, Ronald R. Krijger, Marry M. Heuvel-Eibrink, Federico Comitani, Alice Piapi, Eva Bugallo-Blanco, Christine Thevanesan, Christina Burke, Elena Prigmore, Kirsty Ambridge, Kenny Roberts, Felipe A. Vieira Braga, Tim H. H. Coorens, Ignacio Valle, Anna Wilbrey-Clark, Lira Mamanova, Grant D. Stewart, Vincent J. Gnanapragasam, Dyanne Rampling, Neil Sebire, Nicholas Coleman, Liz Hook, Anne Warren, Muzlifah Haniffa, Marcel Kool, Stefan M. Pfister, John C. Achermann, Xiaoling He, Roger A. Barker, Adam Shlien, Omer A. Bayraktar, Sarah A. Teichmann, Frank C. Holstege, Kerstin B. Meyer, Jarno Drost (), Karin Straathof () and Sam Behjati ()
Additional contact information
Matthew D. Young: Wellcome Genome Campus, Hinxton
Thomas J. Mitchell: Wellcome Genome Campus, Hinxton
Lars Custers: Princess Máxima Center for Pediatric Oncology
Thanasis Margaritis: Princess Máxima Center for Pediatric Oncology
Francisco Morales-Rodriguez: Princess Máxima Center for Pediatric Oncology
Kwasi Kwakwa: Wellcome Genome Campus, Hinxton
Eleonora Khabirova: Wellcome Genome Campus, Hinxton
Gerda Kildisiute: Wellcome Genome Campus, Hinxton
Thomas R. W. Oliver: Wellcome Genome Campus, Hinxton
Ronald R. Krijger: Princess Máxima Center for Pediatric Oncology
Marry M. Heuvel-Eibrink: Princess Máxima Center for Pediatric Oncology
Federico Comitani: The Hospital for Sick Children
Alice Piapi: UCL Great Ormond Street Hospital Institute of Child Health
Eva Bugallo-Blanco: UCL Great Ormond Street Hospital Institute of Child Health
Christine Thevanesan: UCL Great Ormond Street Hospital Institute of Child Health
Christina Burke: UCL Great Ormond Street Hospital Institute of Child Health
Elena Prigmore: Wellcome Genome Campus, Hinxton
Kirsty Ambridge: Wellcome Genome Campus, Hinxton
Kenny Roberts: Wellcome Genome Campus, Hinxton
Felipe A. Vieira Braga: University of Amsterdam
Tim H. H. Coorens: Wellcome Genome Campus, Hinxton
Ignacio Valle: UCL Great Ormond Street Hospital Institute of Child Health
Anna Wilbrey-Clark: Wellcome Genome Campus, Hinxton
Lira Mamanova: Wellcome Genome Campus, Hinxton
Grant D. Stewart: Cambridge University Hospitals NHS Foundation Trust
Vincent J. Gnanapragasam: Cambridge University Hospitals NHS Foundation Trust
Dyanne Rampling: Great Ormond Street Hospital for Children NHS Foundation Trust
Neil Sebire: NIHR Great Ormond Street Hospital BRC and Institute of Child Health
Nicholas Coleman: Cambridge University Hospitals NHS Foundation Trust
Liz Hook: Cambridge University Hospitals NHS Foundation Trust
Anne Warren: Cambridge University Hospitals NHS Foundation Trust
Muzlifah Haniffa: Wellcome Genome Campus, Hinxton
Marcel Kool: Princess Máxima Center for Pediatric Oncology
Stefan M. Pfister: Hopp Children´s Cancer Center Heidelberg (KiTZ)
John C. Achermann: UCL Great Ormond Street Hospital Institute of Child Health
Xiaoling He: University of Cambridge
Roger A. Barker: University of Cambridge
Adam Shlien: The Hospital for Sick Children
Omer A. Bayraktar: Wellcome Genome Campus, Hinxton
Sarah A. Teichmann: Wellcome Genome Campus, Hinxton
Frank C. Holstege: Princess Máxima Center for Pediatric Oncology
Kerstin B. Meyer: Wellcome Genome Campus, Hinxton
Jarno Drost: Princess Máxima Center for Pediatric Oncology
Karin Straathof: UCL Great Ormond Street Hospital Institute of Child Health
Sam Behjati: Wellcome Genome Campus, Hinxton

Nature Communications, 2021, vol. 12, issue 1, 1-19

Abstract: Abstract Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference “cellular signals” in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of “fetalness” with a quantitative measure of immaturity. By contrast, in adult cancers our assessment refutes the suggestion of dedifferentiation towards a fetal state in most cases. We find an intimate connection between developmental mesenchymal populations and childhood renal tumors. We demonstrate the diagnostic potential of our approach with a case study of a cryptic renal tumor. Our findings provide a cellular definition of human renal tumors through an approach that is broadly applicable to human cancer.

Date: 2021
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-021-23949-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23949-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-23949-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().