Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging

Bongjoong Kim, Arvin H. Soepriatna, Woohyun Park, Haesoo Moon, Abigail Cox, Jianchao Zhao, Nevin S. Gupta, Chi Hoon Park, Kyunghun Kim, Yale Jeon, Hanmin Jang, Dong Rip Kim, Hyowon Lee, Kwan-Soo Lee (), Craig J. Goergen () and Chi Hwan Lee ()
Additional contact information
Bongjoong Kim: Purdue University
Arvin H. Soepriatna: Purdue University
Woohyun Park: Purdue University
Haesoo Moon: Purdue University
Abigail Cox: Purdue College of Veterinary Medicine
Jianchao Zhao: Los Alamos National Laboratory
Nevin S. Gupta: Los Alamos National Laboratory
Chi Hoon Park: Los Alamos National Laboratory
Kyunghun Kim: Purdue University
Yale Jeon: Purdue University
Hanmin Jang: Purdue University
Dong Rip Kim: Hanyang University
Hyowon Lee: Purdue University
Kwan-Soo Lee: Los Alamos National Laboratory
Craig J. Goergen: Purdue University
Chi Hwan Lee: Purdue University

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract The growing need for the implementation of stretchable biosensors in the body has driven rapid prototyping schemes through the direct ink writing of multidimensional functional architectures. Recent approaches employ biocompatible inks that are dispensable through an automated nozzle injection system. However, their application in medical practices remains challenged in reliable recording due to their viscoelastic nature that yields mechanical and electrical hysteresis under periodic large strains. Herein, we report sponge-like poroelastic silicone composites adaptable for high-precision direct writing of custom-designed stretchable biosensors, which are soft and insensitive to strains. Their unique structural properties yield a robust coupling to living tissues, enabling high-fidelity recording of spatiotemporal electrophysiological activity and real-time ultrasound imaging for visual feedback. In vivo evaluations of custom-fit biosensors in a murine acute myocardial infarction model demonstrate a potential clinical utility in the simultaneous intraoperative recording and imaging on the epicardium, which may guide definitive surgical treatments.

Date: 2021
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DOI: 10.1038/s41467-021-23959-3

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