Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery

Erfan Dashtimoghadam, Farahnaz Fahimipour, Andrew N. Keith, Foad Vashahi, Pavel Popryadukhin, Mohammad Vatankhah-Varnosfaderani () and Sergei S. Sheiko ()
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Erfan Dashtimoghadam: University of North Carolina at Chapel Hill
Farahnaz Fahimipour: University of North Carolina at Chapel Hill
Andrew N. Keith: University of North Carolina at Chapel Hill
Foad Vashahi: University of North Carolina at Chapel Hill
Pavel Popryadukhin: Institute of Macromolecular Compounds of the Russian Academy of Sciences
Mohammad Vatankhah-Varnosfaderani: University of North Carolina at Chapel Hill
Sergei S. Sheiko: University of North Carolina at Chapel Hill

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Current materials used in biomedical devices do not match tissue’s mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation.

Date: 2021
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DOI: 10.1038/s41467-021-23962-8

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