Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus

Sara Zocher, Rupert W. Overall, Mathias Lesche, Andreas Dahl and Gerd Kempermann ()
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Sara Zocher: German Center for Neurodegenerative Diseases (DZNE) Dresden
Rupert W. Overall: German Center for Neurodegenerative Diseases (DZNE) Dresden
Mathias Lesche: Technische Universität Dresden
Andreas Dahl: Technische Universität Dresden
Gerd Kempermann: German Center for Neurodegenerative Diseases (DZNE) Dresden

Nature Communications, 2021, vol. 12, issue 1, 1-15

Abstract: Abstract The decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Lifestyle interventions can improve brain function during aging, but their influence on age-related epigenetic changes is unknown. Using genome-wide DNA methylation sequencing, we here show that experiencing a stimulus-rich environment counteracts age-related DNA methylation changes in the hippocampal dentate gyrus of mice. Specifically, environmental enrichment prevented the aging-induced CpG hypomethylation at target sites of the methyl-CpG-binding protein Mecp2, which is critical to neuronal function. The genes at which environmental enrichment counteracted aging effects have described roles in neuronal plasticity, neuronal cell communication and adult hippocampal neurogenesis and are dysregulated with age-related cognitive decline in the human brain. Our results highlight the stimulating effects of environmental enrichment on hippocampal plasticity at the level of DNA methylation and give molecular insights into the specific aspects of brain aging that can be counteracted by lifestyle interventions.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23993-1

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DOI: 10.1038/s41467-021-23993-1

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