Ni-catalyzed hydroaminoalkylation of alkynes with amines
Wei-Wei Yao,
Ran Li,
Hao Chen,
Ming-Kai Chen,
Yu-Xin Luan (),
Yi Wang,
Zhi-Xiang Yu () and
Mengchun Ye ()
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Wei-Wei Yao: Nankai University
Ran Li: Nankai University
Hao Chen: Nankai University
Ming-Kai Chen: Nankai University
Yu-Xin Luan: Nankai University
Yi Wang: Peking University
Zhi-Xiang Yu: Peking University
Mengchun Ye: Nankai University
Nature Communications, 2021, vol. 12, issue 1, 1-9
Abstract:
Abstract Allylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but their synthesis via hydroaminoalkylation of alkynes with amines has been a formidable challenge. Here, we report a late transition metal Ni-catalyzed hydroaminoalkylation of alkynes with N-sulfonyl amines, providing a series of allylic amines in up to 94% yield. Double ligands of N-heterocyclic carbene (IPr) and tricyclohexylphosphine (PCy3) effectively promote the reaction.
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24032-9
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DOI: 10.1038/s41467-021-24032-9
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