Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya

Ifedayo M. O. Adetifa (), Sophie Uyoga (), John N. Gitonga, Daisy Mugo, Mark Otiende, James Nyagwange, Henry K. Karanja, James Tuju, Perpetual Wanjiku, Rashid Aman, Mercy Mwangangi, Patrick Amoth, Kadondi Kasera, Wangari Ng’ang’a, Charles Rombo, Christine Yegon, Khamisi Kithi, Elizabeth Odhiambo, Thomas Rotich, Irene Orgut, Sammy Kihara, Christian Bottomley, Eunice W. Kagucia, Katherine E. Gallagher, Anthony Etyang, Shirine Voller, Teresa Lambe, Daniel Wright, Edwine Barasa, Benjamin Tsofa, Philip Bejon, Lynette I. Ochola-Oyier, Ambrose Agweyu, J. Anthony G. Scott and George M. Warimwe
Additional contact information
Ifedayo M. O. Adetifa: KEMRI-Wellcome Trust Research Programme
Sophie Uyoga: KEMRI-Wellcome Trust Research Programme
John N. Gitonga: KEMRI-Wellcome Trust Research Programme
Daisy Mugo: KEMRI-Wellcome Trust Research Programme
Mark Otiende: KEMRI-Wellcome Trust Research Programme
James Nyagwange: KEMRI-Wellcome Trust Research Programme
Henry K. Karanja: KEMRI-Wellcome Trust Research Programme
James Tuju: KEMRI-Wellcome Trust Research Programme
Perpetual Wanjiku: KEMRI-Wellcome Trust Research Programme
Rashid Aman: Ministry of Health, Government of Kenya
Mercy Mwangangi: Ministry of Health, Government of Kenya
Patrick Amoth: Ministry of Health, Government of Kenya
Kadondi Kasera: Ministry of Health, Government of Kenya
Wangari Ng’ang’a: Presidential Policy & Strategy Unit, The Presidency, Government of Kenya
Charles Rombo: Kenya National Blood Transfusion Services, Ministry of Health
Christine Yegon: Kenya National Blood Transfusion Services, Ministry of Health
Khamisi Kithi: Kenya National Blood Transfusion Services, Ministry of Health
Elizabeth Odhiambo: Kenya National Blood Transfusion Services, Ministry of Health
Thomas Rotich: Kenya National Blood Transfusion Services, Ministry of Health
Irene Orgut: Kenya National Blood Transfusion Services, Ministry of Health
Sammy Kihara: Kenya National Blood Transfusion Services, Ministry of Health
Christian Bottomley: London School of Hygiene and Tropical Medicine, Keppel Street
Eunice W. Kagucia: KEMRI-Wellcome Trust Research Programme
Katherine E. Gallagher: KEMRI-Wellcome Trust Research Programme
Anthony Etyang: KEMRI-Wellcome Trust Research Programme
Shirine Voller: KEMRI-Wellcome Trust Research Programme
Teresa Lambe: Nuffield Department of Medicine, Oxford University
Daniel Wright: Nuffield Department of Medicine, Oxford University
Edwine Barasa: KEMRI-Wellcome Trust Research Programme
Benjamin Tsofa: KEMRI-Wellcome Trust Research Programme
Philip Bejon: KEMRI-Wellcome Trust Research Programme
Lynette I. Ochola-Oyier: KEMRI-Wellcome Trust Research Programme
Ambrose Agweyu: KEMRI-Wellcome Trust Research Programme
J. Anthony G. Scott: KEMRI-Wellcome Trust Research Programme
George M. Warimwe: KEMRI-Wellcome Trust Research Programme

Nature Communications, 2021, vol. 12, issue 1, 1-6

Abstract: Abstract Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with apparently low associated mortality.

Date: 2021
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DOI: 10.1038/s41467-021-24062-3

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