Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure

Yosuke Funato, Daisuke Yamazaki, Daisuke Okuzaki, Nobuhiko Yamamoto and Hiroaki Miki ()
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Yosuke Funato: Research Institute for Microbial Diseases, Osaka University
Daisuke Yamazaki: Research Institute for Microbial Diseases, Osaka University
Daisuke Okuzaki: Osaka University
Nobuhiko Yamamoto: Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University
Hiroaki Miki: Research Institute for Microbial Diseases, Osaka University

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Blood pressure has a daily pattern, with higher values in the active period. Its elevation at the onset of the active period substantially increases the risk of fatal cardiovascular events. Renin secretion stimulated by renal sympathetic neurons is considered essential to this process; however, its regulatory mechanism remains largely unknown. Here, we show the importance of transient receptor potential melastatin-related 6 (TRPM6), a Mg2+-permeable cation channel, in augmenting renin secretion in the active period. TRPM6 expression is significantly reduced in the distal convoluted tubule of hypotensive Cnnm2-deficient mice. We generate kidney-specific Trpm6-deficient mice and observe a decrease in blood pressure and a disappearance of its circadian variation. Consistently, renin secretion is not augmented in the active period. Furthermore, renin secretion after pharmacological activation of β-adrenoreceptor, the target of neuronal stimulation, is abrogated, and the receptor expression is decreased in renin-secreting cells. These results indicate crucial roles of TRPM6 in the circadian regulation of blood pressure.

Date: 2021
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DOI: 10.1038/s41467-021-24063-2

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