Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer

Donggeun Lee, Woo Hyuk Jung, Suho Lee, Eui-Sang Yu, Taikjin Lee, Jae Hun Kim, Hyun Seok Song, Kwan Hyi Lee, Seok Lee, Sang-Kook Han, Myung Chul Choi, Dong June Ahn (), Yong-Sang Ryu () and Chulki Kim ()
Additional contact information
Donggeun Lee: Korea Institute of Science and Technology
Woo Hyuk Jung: Korea University
Suho Lee: Korea Advanced Institute of Science and Technology (KAIST)
Eui-Sang Yu: Korea Institute of Science and Technology
Taikjin Lee: Korea Institute of Science and Technology
Jae Hun Kim: Korea Institute of Science and Technology
Hyun Seok Song: Korea Institute of Science and Technology
Kwan Hyi Lee: Korea Institute of Science and Technology
Seok Lee: Korea Institute of Science and Technology
Sang-Kook Han: Yonsei University
Myung Chul Choi: Korea Advanced Institute of Science and Technology (KAIST)
Dong June Ahn: Korea University
Yong-Sang Ryu: Korea Institute of Science and Technology
Chulki Kim: Korea Institute of Science and Technology

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Despite technological advances in biomolecule detections, evaluation of molecular interactions via potentiometric devices under ion-enriched solutions has remained a long-standing problem. To avoid severe performance degradation of bioelectronics by ionic screening effects, we cover probe surfaces of field effect transistors with a single film of the supported lipid bilayer, and realize respectable potentiometric signals from receptor–ligand bindings irrespective of ionic strength of bulky solutions by placing an ion-free water layer underneath the supported lipid bilayer. High-energy X-ray reflectometry together with the circuit analysis and molecular dynamics simulation discovered biochemical findings that effective electrical signals dominantly originated from the sub-nanoscale conformational change of lipids in the course of receptor–ligand bindings. Beyond thorough analysis on the underlying mechanism at the molecular level, the proposed supported lipid bilayer-field effect transistor platform ensures the world-record level of sensitivity in molecular detection with excellent reproducibility regardless of molecular charges and environmental ionic conditions.

Date: 2021
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DOI: 10.1038/s41467-021-24122-8

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