Tailored cobalt-salen complexes enable electrocatalytic intramolecular allylic C–H functionalizations

Chen-Yan Cai, Zheng-Jian Wu, Ji-Ying Liu, Ming Chen, Jinshuai Song and Hai-Chao Xu ()
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Chen-Yan Cai: Xiamen University
Zheng-Jian Wu: Xiamen University
Ji-Ying Liu: Zhengzhou University
Ming Chen: Xiamen University
Jinshuai Song: Zhengzhou University
Hai-Chao Xu: Xiamen University

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Oxidative allylic C–H functionalization is a powerful tool to streamline organic synthesis as it minimizes the need for functional group activation and generates alkenyl-substituted products amenable to further chemical modifications. The intramolecular variants can be used to construct functionalized ring structures but remain limited in scope and by their frequent requirement for noble metal catalysts and stoichiometric chemical oxidants. Here we report an oxidant-free, electrocatalytic approach to achieve intramolecular oxidative allylic C–H amination and alkylation by employing tailored cobalt-salen complexes as catalysts. These reactions proceed through a radical mechanism and display broad tolerance of functional groups and alkene substitution patterns, allowing efficient coupling of di-, tri- and even tetrasubstituted alkenes with N- and C-nucleophiles to furnish high-value heterocyclic and carbocyclic structures.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24125-5

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DOI: 10.1038/s41467-021-24125-5

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