TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice

Yu-chi Shen, Adrienne Niederriter Shami, Lindsay Moritz, Hailey Larose, Gabriel L. Manske, Qianyi Ma, Xianing Zheng, Meena Sukhwani, Michael Czerwinski, Caleb Sultan, Haolin Chen, Stephen J. Gurczynski, Jason R. Spence, Kyle E. Orwig, Michelle Tallquist, Jun Z. Li and Saher Sue Hammoud ()
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Yu-chi Shen: University of Michigan
Adrienne Niederriter Shami: University of Michigan
Lindsay Moritz: University of Michigan
Hailey Larose: University of Michigan
Gabriel L. Manske: University of Michigan
Qianyi Ma: University of Michigan
Xianing Zheng: University of Michigan
Meena Sukhwani: University of Pittsburgh School of Medicine
Michael Czerwinski: University of Michigan
Caleb Sultan: University of Michigan
Haolin Chen: Bloomberg School of Public Health
Stephen J. Gurczynski: University of Michigan
Jason R. Spence: University of Michigan
Kyle E. Orwig: University of Pittsburgh School of Medicine
Michelle Tallquist: Center for Cardiovascular Research
Jun Z. Li: University of Michigan
Saher Sue Hammoud: University of Michigan

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Testicular development and function rely on interactions between somatic cells and the germline, but similar to other organs, regenerative capacity declines in aging and disease. Whether the adult testis maintains a reserve progenitor population remains uncertain. Here, we characterize a recently identified mouse testis interstitial population expressing the transcription factor Tcf21. We found that TCF21lin cells are bipotential somatic progenitors present in fetal testis and ovary, maintain adult testis homeostasis during aging, and act as potential reserve somatic progenitors following injury. In vitro, TCF21lin cells are multipotent mesenchymal progenitors which form multiple somatic lineages including Leydig and myoid cells. Additionally, TCF21+ cells resemble resident fibroblast populations reported in other organs having roles in tissue homeostasis, fibrosis, and regeneration. Our findings reveal that the testis, like other organs, maintains multipotent mesenchymal progenitors that can be potentially leveraged in development of future therapies for hypoandrogenism and/or infertility.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24130-8

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DOI: 10.1038/s41467-021-24130-8

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