scGCN is a graph convolutional networks algorithm for knowledge transfer in single cell omics

Qianqian Song, Jing Su () and Wei Zhang ()
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Qianqian Song: Wake Forest Baptist Medical Center
Jing Su: Indiana University School of Medicine
Wei Zhang: Wake Forest Baptist Medical Center

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Single-cell omics is the fastest-growing type of genomics data in the literature and public genomics repositories. Leveraging the growing repository of labeled datasets and transferring labels from existing datasets to newly generated datasets will empower the exploration of single-cell omics data. However, the current label transfer methods have limited performance, largely due to the intrinsic heterogeneity among cell populations and extrinsic differences between datasets. Here, we present a robust graph artificial intelligence model, single-cell Graph Convolutional Network (scGCN), to achieve effective knowledge transfer across disparate datasets. Through benchmarking with other label transfer methods on a total of 30 single cell omics datasets, scGCN consistently demonstrates superior accuracy on leveraging cells from different tissues, platforms, and species, as well as cells profiled at different molecular layers. scGCN is implemented as an integrated workflow as a python software, which is available at https://github.com/QSong-github/scGCN .

Date: 2021
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DOI: 10.1038/s41467-021-24172-y

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