Organization of the inputs and outputs of the mouse superior colliculus

Nora L. Benavidez, Michael S. Bienkowski, Muye Zhu, Luis H. Garcia, Marina Fayzullina, Lei Gao, Ian Bowman, Lin Gou, Neda Khanjani, Kaelan R. Cotter, Laura Korobkova, Marlene Becerra, Chunru Cao, Monica Y. Song, Bin Zhang, Seita Yamashita, Amanda J. Tugangui, Brian Zingg, Kasey Rose, Darrick Lo, Nicholas N. Foster, Tyler Boesen, Hyun-Seung Mun, Sarvia Aquino, Ian R. Wickersham, Giorgio A. Ascoli, Houri Hintiryan and Hong-Wei Dong ()
Additional contact information
Nora L. Benavidez: University of Southern California
Michael S. Bienkowski: University of Southern California
Muye Zhu: University of Southern California
Luis H. Garcia: University of Southern California
Marina Fayzullina: University of Southern California
Lei Gao: University of Southern California
Ian Bowman: University of Southern California
Lin Gou: University of Southern California
Neda Khanjani: University of Southern California
Kaelan R. Cotter: University of Southern California
Laura Korobkova: University of Southern California
Marlene Becerra: University of Southern California
Chunru Cao: University of Southern California
Monica Y. Song: University of Southern California
Bin Zhang: University of Southern California
Seita Yamashita: University of Southern California
Amanda J. Tugangui: University of Southern California
Brian Zingg: University of Southern California
Kasey Rose: University of Southern California
Darrick Lo: University of Southern California
Nicholas N. Foster: University of Southern California
Tyler Boesen: University of Southern California
Hyun-Seung Mun: University of Southern California
Sarvia Aquino: University of Southern California
Ian R. Wickersham: Massachusetts Institute of Technology
Giorgio A. Ascoli: George Mason University
Houri Hintiryan: University of Southern California
Hong-Wei Dong: University of Southern California

Nature Communications, 2021, vol. 12, issue 1, 1-20

Abstract: Abstract The superior colliculus (SC) receives diverse and robust cortical inputs to drive a range of cognitive and sensorimotor behaviors. However, it remains unclear how descending cortical input arising from higher-order associative areas coordinate with SC sensorimotor networks to influence its outputs. Here, we construct a comprehensive map of all cortico-tectal projections and identify four collicular zones with differential cortical inputs: medial (SC.m), centromedial (SC.cm), centrolateral (SC.cl) and lateral (SC.l). Further, we delineate the distinctive brain-wide input/output organization of each collicular zone, assemble multiple parallel cortico-tecto-thalamic subnetworks, and identify the somatotopic map in the SC that displays distinguishable spatial properties from the somatotopic maps in the neocortex and basal ganglia. Finally, we characterize interactions between those cortico-tecto-thalamic and cortico-basal ganglia-thalamic subnetworks. This study provides a structural basis for understanding how SC is involved in integrating different sensory modalities, translating sensory information to motor command, and coordinating different actions in goal-directed behaviors.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24241-2

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DOI: 10.1038/s41467-021-24241-2

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