Genetic influences on hub connectivity of the human connectome

Aurina Arnatkeviciute (), Ben D. Fulcher, Stuart Oldham, Jeggan Tiego, Casey Paquola, Zachary Gerring, Kevin Aquino, Ziarih Hawi, Beth Johnson, Gareth Ball, Marieke Klein, Gustavo Deco, Barbara Franke, Mark A. Bellgrove and Alex Fornito
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Aurina Arnatkeviciute: Monash University
Ben D. Fulcher: Monash University
Stuart Oldham: Monash University
Jeggan Tiego: Monash University
Casey Paquola: McGill University
Zachary Gerring: QIMR Berghofer Medical Research Institute
Kevin Aquino: Monash University
Ziarih Hawi: Monash University
Beth Johnson: Monash University
Gareth Ball: Murdoch Children’s Research Institute
Marieke Klein: Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour
Gustavo Deco: Monash University
Barbara Franke: Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour
Mark A. Bellgrove: Monash University
Alex Fornito: Monash University

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Brain network hubs are both highly connected and highly inter-connected, forming a critical communication backbone for coherent neural dynamics. The mechanisms driving this organization are poorly understood. Using diffusion-weighted magnetic resonance imaging in twins, we identify a major role for genes, showing that they preferentially influence connectivity strength between network hubs of the human connectome. Using transcriptomic atlas data, we show that connected hubs demonstrate tight coupling of transcriptional activity related to metabolic and cytoarchitectonic similarity. Finally, comparing over thirteen generative models of network growth, we show that purely stochastic processes cannot explain the precise wiring patterns of hubs, and that model performance can be improved by incorporating genetic constraints. Our findings indicate that genes play a strong and preferential role in shaping the functionally valuable, metabolically costly connections between connectome hubs.

Date: 2021
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DOI: 10.1038/s41467-021-24306-2

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