Reduction of corpus callosum activity during whisking leads to interhemispheric decorrelation

Yael Oran, Yonatan Katz, Michael Sokoletsky, Katayun Cohen-Kashi Malina and Ilan Lampl ()
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Yael Oran: Weizmann Institute of Science
Yonatan Katz: Weizmann Institute of Science
Michael Sokoletsky: Weizmann Institute of Science
Katayun Cohen-Kashi Malina: Weizmann Institute of Science
Ilan Lampl: Weizmann Institute of Science

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Interhemispheric correlation between homotopic areas is a major hallmark of cortical physiology and is believed to emerge through the corpus callosum. However, how interhemispheric correlations and corpus callosum activity are affected by behavioral states remains unknown. We performed laminar extracellular and intracellular recordings simultaneously from both barrel cortices in awake mice. We find robust interhemispheric correlations of both spiking and synaptic activities that are reduced during whisking compared to quiet wakefulness. Accordingly, optogenetic inactivation of one hemisphere reveals that interhemispheric coupling occurs only during quiet wakefulness, and chemogenetic inactivation of callosal terminals reduces interhemispheric correlation especially during quiet wakefulness. Moreover, in contrast to the generally elevated firing rate observed during whisking epochs, we find a marked decrease in the activity of imaged callosal fibers. Our results indicate that the reduction in interhemispheric coupling and correlations during active behavior reflects the specific reduction in the activity of callosal neurons.

Date: 2021
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DOI: 10.1038/s41467-021-24310-6

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