Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women

Babatunde Adedokun, Zhaohui Du, Guimin Gao, Thomas U. Ahearn, Kathryn L. Lunetta, Gary Zirpoli, Jonine Figueroa, Esther M. John, Leslie Bernstein, Wei Zheng, Jennifer J. Hu, Regina G. Ziegler, Sarah Nyante, Elisa V. Bandera, Sue A. Ingles, Michael F. Press, Sandra L. Deming-Halverson, Jorge L. Rodriguez-Gil, Song Yao, Temidayo O. Ogundiran, Oladosu Ojengbede, William Blot, Melissa A. Troester, Katherine L. Nathanson, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Peter N. Fiorica, Lara E. Sucheston-Campbell, Jeannette T. Bensen, Lawrence H. Kushi, Gabriela Torres-Mejia, Donglei Hu, Laura Fejerman, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Kyriaki Michailidou, Paul D. P. Pharoah, Qin Wang, Dale P. Sandler, Jack A. Taylor, Katie M. O’Brien, Cari M. Kitahara, Adeyinka G. Falusi, Chinedum Babalola, Joel Yarney, Baffour Awuah, Beatrice Addai-Wiafe, Stephen J. Chanock, Andrew F. Olshan, Christine B. Ambrosone, David V. Conti, Elad Ziv, Olufunmilayo I. Olopade, Montserrat Garcia-Closas, Julie R. Palmer, Christopher A. Haiman () and Dezheng Huo ()
Additional contact information
Babatunde Adedokun: University of Chicago
Zhaohui Du: University of Southern California
Guimin Gao: University of Chicago
Thomas U. Ahearn: National Cancer Institute
Kathryn L. Lunetta: Boston University School of Public Health
Gary Zirpoli: Boston University
Jonine Figueroa: University of Edinburgh
Esther M. John: Stanford University School of Medicine
Leslie Bernstein: City of Hope Comprehensive Cancer Center
Wei Zheng: Vanderbilt University
Jennifer J. Hu: University of Miami
Regina G. Ziegler: National Cancer Institute
Sarah Nyante: University of North Carolina
Elisa V. Bandera: Rutgers Cancer Institute of New Jersey
Sue A. Ingles: University of Southern California
Michael F. Press: University of Southern California
Sandra L. Deming-Halverson: Vanderbilt University
Jorge L. Rodriguez-Gil: National Human Genome Research Institute, NIH
Song Yao: Roswell Park Comprehensive Cancer Center
Temidayo O. Ogundiran: University of Ibadan
Oladosu Ojengbede: University of Ibadan
William Blot: Vanderbilt University
Melissa A. Troester: University of North Carolina
Katherine L. Nathanson: University of Pennsylvania
Anselm Hennis: University of the West Indies
Barbara Nemesure: Stony Brook University
Stefan Ambs: National Cancer Institute
Peter N. Fiorica: University of Chicago
Lara E. Sucheston-Campbell: The Ohio State University
Jeannette T. Bensen: University of North Carolina
Lawrence H. Kushi: Kaiser Permanente Northern California
Gabriela Torres-Mejia: Instituto Nacional de Salud Publica
Donglei Hu: University of California San Francisco
Laura Fejerman: University of California San Francisco
Manjeet K. Bolla: University of Cambridge
Joe Dennis: University of Cambridge
Alison M. Dunning: University of Cambridge
Douglas F. Easton: University of Cambridge
Kyriaki Michailidou: The Cyprus Institute of Neurology & Genetics
Paul D. P. Pharoah: University of Cambridge
Qin Wang: University of Cambridge
Dale P. Sandler: NIH
Jack A. Taylor: NIH
Katie M. O’Brien: NIH
Cari M. Kitahara: National Cancer Institute
Adeyinka G. Falusi: University of Ibadan
Chinedum Babalola: University of Ibadan
Joel Yarney: Korle Bu Teaching Hospital
Baffour Awuah: Komfo Anokye Teaching Hospital
Beatrice Addai-Wiafe: Peace and Love Hospital
Stephen J. Chanock: National Cancer Institute
Andrew F. Olshan: University of North Carolina
Christine B. Ambrosone: Roswell Park Comprehensive Cancer Center
David V. Conti: University of Southern California
Elad Ziv: University of California San Francisco
Olufunmilayo I. Olopade: University of Chicago
Montserrat Garcia-Closas: National Cancer Institute
Julie R. Palmer: Boston University
Christopher A. Haiman: University of Southern California
Dezheng Huo: University of Chicago

Nature Communications, 2021, vol. 12, issue 1, 1-8

Abstract: Abstract Our study describes breast cancer risk loci using a cross-ancestry GWAS approach. We first identify variants that are associated with breast cancer at P

Date: 2021
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DOI: 10.1038/s41467-021-24327-x

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