Tissue-specific 5-hydroxymethylcytosine landscape of the human genome

Bo He, Chao Zhang, Xiaoxue Zhang, Yu Fan, Hu Zeng, Jun’e Liu, Haowei Meng, Dongsheng Bai, Jinying Peng, Qian Zhang (), Wei Tao () and Chengqi Yi ()
Additional contact information
Bo He: Peking University
Chao Zhang: Peking University
Xiaoxue Zhang: Peking University
Yu Fan: Peking University First Hospital
Hu Zeng: Peking University
Jun’e Liu: Peking University
Haowei Meng: Peking University
Dongsheng Bai: Peking University
Jinying Peng: Peking University
Qian Zhang: Peking University First Hospital
Wei Tao: Peking University
Chengqi Yi: Peking University

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract 5-Hydroxymethylcytosine (5hmC) is an important epigenetic mark that regulates gene expression. Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues. We found that 5hmC preferentially decorates gene bodies and outperforms gene body 5mC in reflecting gene expression. Approximately one-third of 5hmC peaks are tissue-specific differentially-hydroxymethylated regions (tsDhMRs), which are deposited in regions that potentially regulate the expression of nearby tissue-specific functional genes. In addition, tsDhMRs are enriched with tissue-specific transcription factors and may rewire tissue-specific gene expression networks. Moreover, tsDhMRs are associated with single-nucleotide polymorphisms identified by genome-wide association studies and are linked to tissue-specific phenotypes and diseases. Collectively, our results show the tissue-specific 5hmC landscape of the human genome and demonstrate that 5hmC serves as a fundamental regulatory element affecting tissue-specific gene expression programs and functions.

Date: 2021
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-24425-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24425-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-24425-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().