Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis

Shuo Li, Zorawar S. Noor, Weihua Zeng, Mary L. Stackpole, Xiaohui Ni, Yonggang Zhou, Zuyang Yuan, Wing Hung Wong, Vatche G. Agopian, Steven M. Dubinett, Frank Alber, Wenyuan Li (), Edward B. Garon () and Xianghong Jasmine Zhou ()
Additional contact information
Shuo Li: University of California at Los Angeles
Zorawar S. Noor: David Geffen School of Medicine at UCLA
Weihua Zeng: University of California at Los Angeles
Mary L. Stackpole: University of California at Los Angeles
Xiaohui Ni: EarlyDiagnostics Inc
Yonggang Zhou: University of California at Los Angeles
Zuyang Yuan: University of California at Los Angeles
Wing Hung Wong: Stanford University
Vatche G. Agopian: David Geffen School of Medicine at UCLA
Steven M. Dubinett: University of California at Los Angeles
Frank Alber: University of California at Los Angeles
Wenyuan Li: University of California at Los Angeles
Edward B. Garon: David Geffen School of Medicine at UCLA
Xianghong Jasmine Zhou: University of California at Los Angeles

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Cell-free DNA (cfDNA) is attractive for many applications, including detecting cancer, identifying the tissue of origin, and monitoring. A fundamental task underlying these applications is SNV calling from cfDNA, which is hindered by the very low tumor content. Thus sensitive and accurate detection of low-frequency mutations (

Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-24457-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24457-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-24457-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().